ENSG00000188886


Homo sapiens

Features
Gene ID: ENSG00000188886
  
Biological name :ASTL
  
Synonyms : astacin like metalloendopeptidase / ASTL / Q6HA08
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q11.2
Gene start: 96123850
Gene end: 96138436
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000343674
NCBI entrez gene - 431705     See in Manteia.
OMIM - 608860
RefSeq - XM_011511208
RefSeq - NM_001002036
RefSeq - XM_011511206
RefSeq - XM_011511207
RefSeq - XM_011511205
RefSeq Peptide - NP_001002036
swissprot - Q6HA08
Ensembl - ENSG00000188886
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 he1.1ENSDARG00000023656Danio rerio
 he1.2ENSDARG00000019122Danio rerio
 he1.3ENSDARG00000022670Danio rerio
 ENSGALG00000043984Gallus gallus
 ASTLENSGALG00000037220Gallus gallus
 AstlENSMUSG00000050468Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MEP1B / Q16820 / meprin A subunit betaENSG0000014143427
MEP1A / Q16819 / meprin A subunit alphaENSG0000011281824


Protein motifs (from Interpro)
Interpro ID Name
 IPR001506  Peptidase M12A
 IPR006026  Peptidase, metallopeptidase
 IPR024079  Metallopeptidase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0010954 positive regulation of protein processing IEA
 biological_processGO:0060468 prevention of polyspermy IEA
 biological_processGO:2000360 negative regulation of binding of sperm to zona pellucida IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0060473 cortical granule ISS
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070001 aspartic-type peptidase activity ISS
 molecular_functionGO:0070002 glutamic-type peptidase activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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