ENSMUSG00000024014


Mus musculus

Features
Gene ID: ENSMUSG00000024014
  
Biological name :Pim1
  
Synonyms : Pim1 / Pim-1 proto-oncogene, serine/threonine kinase
  
Possible biological names infered from orthology : P11309
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 29490812
Gene end: 29496111
  
Corresponding Affymetrix probe sets: 10443527 (MoGene1.0st)   1423006_at (Mouse Genome 430 2.0 Array)   1435458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024811
NCBI entrez gene - 18712     See in Manteia.
MGI - MGI:97584
RefSeq - NM_008842
RefSeq Peptide - NP_032868
swissprot - Q8CFN8
Ensembl - ENSMUSG00000024014
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pim1ENSDARG00000100020Danio rerio
 PIM1ENSGALG00000038902Gallus gallus
 PIM1ENSG00000137193Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pim3 / P58750 / proviral integration site 3 / Q86V86* / Pim-3 proto-oncogene, serine/threonine kinase*ENSMUSG0000003582869
Pim2 / Q62070 / Serine/threonine-protein kinase pim-2 / Q9P1W9* / Pim-2 proto-oncogene, serine/threonine kinase*ENSMUSG0000003115553
Pask / Q8CEE6 / PAS domain-containing serine/threonine-protein kinase / Q96RG2* / PAS domain containing serine/threonine kinase*ENSMUSG0000002627434


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017348  Serine/threonine-protein kinase pim-1/2/3
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0070561 vitamin D receptor signaling pathway IEA
 biological_processGO:1905062 positive regulation of cardioblast proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0043024 ribosomal small subunit binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0001588 hemoglobin abnormalities "defects in the levels or the function of the oxygen-carrying protein of erythrocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm2Arge/Brca1tm2Arge
Genetic Background: involves: 129

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: a/a6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkar2btm1Gsm/Prkar2btm1Gsm
Genetic Background: B6.129-Prkar2btm1Gsm

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003133 increased number of early pro-B cells "greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain" [J:91592, smb:Susan M. Bello, Mouse Genome Informatics Curator, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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