ENSMUSG00000026274


Mus musculus

Features
Gene ID: ENSMUSG00000026274
  
Biological name :Pask
  
Synonyms : PAS domain-containing serine/threonine-protein kinase / Pask / Q8CEE6
  
Possible biological names infered from orthology : PAS domain containing serine/threonine kinase / Q96RG2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 93308770
Gene end: 93343482
  
Corresponding Affymetrix probe sets: 10356780 (MoGene1.0st)   1450993_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027493
Ensembl peptide - ENSMUSP00000120104
NCBI entrez gene - 269224     See in Manteia.
MGI - MGI:2155936
RefSeq - XM_017321037
RefSeq - NM_080850
RefSeq - XM_006529665
RefSeq - XM_006529666
RefSeq - XM_006529667
RefSeq Peptide - NP_543126
swissprot - Q8CEE6
swissprot - D3YUI8
Ensembl - ENSMUSG00000026274
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 paskENSDARG00000075008Danio rerio
 PASKENSGALG00000006016Gallus gallus
 PASKENSG00000115687Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pim3 / P58750 / proviral integration site 3 / Q86V86* / Pim-3 proto-oncogene, serine/threonine kinase*ENSMUSG000000358288
Pim1 / Pim-1 proto-oncogene, serine/threonine kinase / P11309*ENSMUSG000000240148
Pim2 / Q62070 / Serine/threonine-protein kinase pim-2 / Q9P1W9* / Pim-2 proto-oncogene, serine/threonine kinase*ENSMUSG000000311558


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043576 regulation of respiratory gaseous exchange IMP
 biological_processGO:0045719 negative regulation of glycogen biosynthetic process IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0070092 regulation of glucagon secretion IMP
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002338 abnormal pulmonary ventilation "anomaly in the total volume of gas per minute inspired or expired " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ikbkgm1Btlr/Y
Genetic Background: C57BL/6J-Ikbkgm1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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