ENSG00000137193


Homo sapiens

Features
Gene ID: ENSG00000137193
  
Biological name :PIM1
  
Synonyms : P11309 / PIM1 / Pim-1 proto-oncogene, serine/threonine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.2
Gene start: 37170203
Gene end: 37175426
  
Corresponding Affymetrix probe sets: 209193_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362608
NCBI entrez gene - 5292     See in Manteia.
OMIM - 164960
RefSeq - NM_001243186
RefSeq - NM_002648
RefSeq Peptide - NP_001230115
RefSeq Peptide - NP_002639
swissprot - P11309
swissprot - A0A024RD25
Ensembl - ENSG00000137193
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pim1ENSDARG00000100020Danio rerio
 PIM1ENSGALG00000038902Gallus gallus
 Pim1ENSMUSG00000024014Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIM3 / Q86V86 / Pim-3 proto-oncogene, serine/threonine kinaseENSG0000019835569
PIM2 / Q9P1W9 / Pim-2 proto-oncogene, serine/threonine kinaseENSG0000010209655
PASK / Q96RG2 / PAS domain containing serine/threonine kinaseENSG0000011568733


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017348  Serine/threonine-protein kinase pim-1/2/3
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IDA
 biological_processGO:0070561 vitamin D receptor signaling pathway IMP
 biological_processGO:1905062 positive regulation of cardioblast proliferation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030145 manganese ion binding IDA
 molecular_functionGO:0043024 ribosomal small subunit binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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