ENSMUSG00000024026


Mus musculus

Features
Gene ID: ENSMUSG00000024026
  
Biological name :Glo1
  
Synonyms : Glo1 / Lactoylglutathione lyase / Q9CPU0
  
Possible biological names infered from orthology : glyoxalase I / Q04760
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 30592866
Gene end: 30612659
  
Corresponding Affymetrix probe sets: 10449644 (MoGene1.0st)   10471675 (MoGene1.0st)   1424108_at (Mouse Genome 430 2.0 Array)   1424109_a_at (Mouse Genome 430 2.0 Array)   1436070_at (Mouse Genome 430 2.0 Array)   1451240_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024823
Ensembl peptide - ENSMUSP00000126586
NCBI entrez gene - 109801     See in Manteia.
MGI - MGI:95742
RefSeq - NM_001113560
RefSeq - NM_025374
RefSeq Peptide - NP_001107032
RefSeq Peptide - NP_079650
swissprot - Q9CPU0
swissprot - A5GZX3
Ensembl - ENSMUSG00000024026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glo1ENSDARG00000068978Danio rerio
 GLO1ENSGALG00000010127Gallus gallus
 GLO1ENSG00000124767Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004360  Glyoxalase/fosfomycin resistance/dioxygenase domain
 IPR004361  Glyoxalase I
 IPR018146  Glyoxalase I, conserved site
 IPR029068  Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
 IPR037523  Vicinal oxygen chelate (VOC) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006749 glutathione metabolic process IEA
 biological_processGO:0009438 methylglyoxal metabolic process IEA
 biological_processGO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IC
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 molecular_functionGO:0004462 lactoylglutathione lyase activity ISO
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024026 Glo1 / Q9CPU0 / Lactoylglutathione lyase / Q04760* / glyoxalase I*  / complex






 

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