ENSMUSG00000024052


Mus musculus

Features
Gene ID: ENSMUSG00000024052
  
Biological name :Lpin2
  
Synonyms : Lpin2 / Mus musculus lipin 2 (Lpin2), transcript variant 3, mRNA. / Q99PI5
  
Possible biological names infered from orthology : lipin 2 / Q92539
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.3
Gene start: 71182560
Gene end: 71249817
  
Corresponding Affymetrix probe sets: 10446656 (MoGene1.0st)   1446316_at (Mouse Genome 430 2.0 Array)   1452836_at (Mouse Genome 430 2.0 Array)   1452837_at (Mouse Genome 430 2.0 Array)   1460290_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115061
Ensembl peptide - ENSMUSP00000119282
Ensembl peptide - ENSMUSP00000120634
Ensembl peptide - ENSMUSP00000127035
Ensembl peptide - ENSMUSP00000118610
NCBI entrez gene - 64898     See in Manteia.
MGI - MGI:1891341
RefSeq - XM_017317606
RefSeq - NM_001164885
RefSeq - NM_001357791
RefSeq - NM_022882
RefSeq - XM_006524786
RefSeq - XM_006524787
RefSeq - XM_006524788
RefSeq Peptide - NP_075020
RefSeq Peptide - NP_001344720
RefSeq Peptide - NP_001158357
swissprot - D6RH34
swissprot - Q99PI5
swissprot - F6VTY5
swissprot - E9PWN0
Ensembl - ENSMUSG00000024052
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lpin2ENSDARG00000061214Danio rerio
 LPIN2ENSGALG00000014836Gallus gallus
 LPIN2ENSG00000101577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lpin1 / Mus musculus lipin 1 (Lpin1), transcript variant 4, mRNA. / Q14693* / lipin 1*ENSMUSG0000002059347
Lpin3 / Q99PI4 / Phosphatidate phosphatase LPIN3 / Q9BQK8* / lipin 3*ENSMUSG0000002741241


Protein motifs (from Interpro)
Interpro ID Name
 IPR007651  Lipin, N-terminal
 IPR013209  Lipin/Ned1/Smp2 (LNS2)
 IPR023214  HAD superfamily
 IPR031315  LNS2/PITP
 IPR031703  Lipin, middle domain
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0009062 fatty acid catabolic process IBA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019432 triglyceride biosynthetic process IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0008195 phosphatidate phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC
Synthesis of PE
Depolymerisation of the Nuclear Lamina
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0009709 hydrometra "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

Allelic Composition: Lpin2tm1b(KOMP)Wtsi/Lpin2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lpin2tm1b(KOMP)Wtsi/Tcp

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Thrbtm3.1Df/Thrbtm3.1Df
Genetic Background: B6J.Cg-Thrbtm3.1Df

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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