ENSMUSG00000024116


Mus musculus

Features
Gene ID: ENSMUSG00000024116
  
Biological name :Prss21
  
Synonyms : protease, serine 21 / Prss21 / Q9JHJ7
  
Possible biological names infered from orthology : Q9Y6M0 / serine protease 21
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 23868056
Gene end: 23873114
  
Corresponding Affymetrix probe sets: 10442363 (MoGene1.0st)   1419623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024928
NCBI entrez gene - 57256     See in Manteia.
MGI - MGI:1916698
RefSeq - XM_011246542
RefSeq - NM_020487
RefSeq Peptide - NP_065233
swissprot - Q54AE4
swissprot - Q9JHJ7
Ensembl - ENSMUSG00000024116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU571315.2ENSDARG00000101956Danio rerio
 CU571315.3ENSDARG00000101990Danio rerio
 prss60.1ENSDARG00000070713Danio rerio
 prss60.2ENSDARG00000055644Danio rerio
 prss60.3ENSDARG00000070710Danio rerio
 si:ch73-182e20.4ENSDARG00000102727Danio rerio
 si:dkey-16l2.17ENSDARG00000027196Danio rerio
 si:dkey-32n7.7ENSDARG00000063444Danio rerio
 si:dkey-32n7.9ENSDARG00000071841Danio rerio
 si:dkeyp-93a5.2ENSDARG00000052064Danio rerio
 si:dkeyp-93a5.2ENSDARG00000100953Danio rerio
 si:dkeyp-93a5.3ENSDARG00000096975Danio rerio
 zgc:100868ENSDARG00000004748Danio rerio
 zgc:112038ENSDARG00000046140Danio rerio
 zgc:123217ENSDARG00000059026Danio rerio
 zgc:123295ENSDARG00000056324Danio rerio
 zgc:153968ENSDARG00000061858Danio rerio
 zgc:163079ENSDARG00000056773Danio rerio
 zgc:165423ENSDARG00000052905Danio rerio
 zgc:92313ENSDARG00000040513Danio rerio
 PRSS21ENSG00000007038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prss41 / Q920S2 / Serine protease 41 / Q7RTY9*ENSMUSG0000002411449
Prss32 / protease, serine 32ENSMUSG0000004899238
Prss48 / Q14B25 / Serine protease 48 / Q7RTY5*ENSMUSG0000004901337
Tpsg1 / tryptase gamma 1 / Q9NRR2*ENSMUSG0000003320037
Prss27 / Q8BJR6 / Serine protease 27 / Q9BQR3*ENSMUSG0000005076236
Prss8 / protease, serine 8 (prostasin) / Q16651* / serine protease 8*ENSMUSG0000003080035
Prss33 / Q80WM7 / Serine protease 33 / Q8NF86*ENSMUSG0000004962034
Prss42 / Q8VIF2 / Serine protease 42 / Q7Z5A4*ENSMUSG0000004466434
Prss30 / Q9QYZ9 / Serine protease 30 ENSMUSG0000002412434
Prss44 / Q402U7 / Serine protease 44 ENSMUSG0000003249333
Prss22 / protease, serine 22 / Q9GZN4* / serine protease 22*ENSMUSG0000004502732
Prss45 / Q8K4I7 / Inactive serine protease 45 / Q7RTY3* / AC109583.3* / serine protease 45*ENSMUSG0000004725731
A6H6T1 / Prss40 / Serine protease 40 ENSMUSG0000003752930
Prss43 / protease, serine 43ENSMUSG0000005839830
Prss47ENSMUSG0000009065830
Prss38 / Q3UKY7 / Serine protease 38 / A1L453*ENSMUSG0000004929128
O70169 / Prss39 / Inactive serine protease 39 ENSMUSG0000002612528


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR034380  Testisin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007283 spermatogenesis TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0
Genetic Background: Not Specified

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnq3tm1.1Naas/Kcnq3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss21tm1Anta/Prss21tm1Anta
Genetic Background: involves: NIH Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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