ENSMUSG00000024121


Mus musculus

Features
Gene ID: ENSMUSG00000024121
  
Biological name :Atp6v0c
  
Synonyms : Atp6v0c / ATPase, H+ transporting, lysosomal V0 subunit C / P63082
  
Possible biological names infered from orthology : ATPase H+ transporting V0 subunit c / P27449
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 24163866
Gene end: 24169702
  
Corresponding Affymetrix probe sets: 10448455 (MoGene1.0st)   10537316 (MoGene1.0st)   10549653 (MoGene1.0st)   1416392_a_at (Mouse Genome 430 2.0 Array)   1435732_x_at (Mouse Genome 430 2.0 Array)   1438925_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024932
Ensembl peptide - ENSMUSP00000122843
Ensembl peptide - ENSMUSP00000121464
Ensembl peptide - ENSMUSP00000111059
NCBI entrez gene - 11984     See in Manteia.
MGI - MGI:88116
RefSeq - NM_009729
RefSeq Peptide - NP_033859
swissprot - D3Z3B2
swissprot - A3KML5
swissprot - E9Q9C5
swissprot - P63082
Ensembl - ENSMUSG00000024121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp6v0caENSDARG00000057853Danio rerio
 atp6v0cbENSDARG00000036577Danio rerio
 ATP6V0CENSGALG00000009229Gallus gallus
 P27449ENSG00000185883Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000245  V-ATPase proteolipid subunit
 IPR002379  V-ATPase proteolipid subunit C-like domain
 IPR011555  V-ATPase proteolipid subunit C, eukaryotic
 IPR035921  F/V-ATP synthase subunit C superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007035 vacuolar acidification TAS
 biological_processGO:0007042 lysosomal lumen acidification TAS
 biological_processGO:0015991 ATP hydrolysis coupled proton transport IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway ISO
 cellular_componentGO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain IBA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005774 vacuolar membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016471 vacuolar proton-transporting V-type ATPase complex TAS
 cellular_componentGO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain IEA
 cellular_componentGO:0033179 proton-transporting V-type ATPase, V0 domain IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008553 proton-exporting ATPase activity, phosphorylative mechanism ISA
 molecular_functionGO:0015078 proton transmembrane transporter activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0046961 proton-transporting ATPase activity, rotational mechanism IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Neutrophil degranulation
Insulin receptor recycling
Transferrin endocytosis and recycling
Ion channel transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024121 P63082 / Atp6v0c / ATPase, H+ transporting, lysosomal V0 subunit C / P27449* / ATPase H+ transporting V0 subunit c*  / complex






 

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contact: otassy@igbmc.fr