ENSMUSG00000024173


Mus musculus

Features
Gene ID: ENSMUSG00000024173
  
Biological name :Tpsab1
  
Synonyms : Tpsab1 / tryptase alpha/beta 1
  
Possible biological names infered from orthology : P20231 / Q15661 / Q9BZJ3 / TPSB2 / TPSD1 / tryptase beta 2 (gene/pseudogene) / tryptase delta 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25343245
Gene end: 25345562
  
Corresponding Affymetrix probe sets: 10448916 (MoGene1.0st)   1426175_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120741
NCBI entrez gene - 100503895     See in Manteia.
MGI - MGI:96943
RefSeq - NM_031187
RefSeq Peptide - NP_112464
swissprot - E9PY32
Ensembl - ENSMUSG00000024173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q15661ENSG00000172236Homo sapiens
 TPSB2ENSG00000197253Homo sapiens
 TPSD1ENSG00000095917Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpsb2 / TPSD1* / Q9BZJ3* / TPSAB1* / P20231* / Q15661* / tryptase delta 1* / tryptase alpha/beta 1* / tryptase beta 2 (gene/pseudogene)*ENSMUSG0000003382562
Prss34 / protease, serine 34ENSMUSG0000005639946
Prss29ENSMUSG0000003403942
Prss28ENSMUSG0000002417141
Prss46 / Q5M8S2 / Serine protease 46 ENSMUSG0000004971933
Prss50 / Q8BLH5 / Probable threonine protease PRSS50 / Q9UI38* / serine protease 50*ENSMUSG0000004875231


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Tpsab1m1/Tpsab1m1,Tpsb2tm1(cre)Adch/Tpsb2tm1(cre)Adch
Genetic Background: B6.Cg-Tpsb2tm1(cre)Adch Tpsab1m1

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tpsab1m1/Tpsab1m1,Tpsb2tm1(cre)Adch/Tpsb2tm1(cre)Adch
Genetic Background: B6.Cg-Tpsb2tm1(cre)Adch Tpsab1m1

Allelic Composition: Tpsab1m1/Tpsab1m1
Genetic Background: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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