ENSG00000172236


Homo sapiens

Features
Gene ID: ENSG00000172236
  
Biological name :TPSAB1
  
Synonyms : Q15661 / TPSAB1 / tryptase alpha/beta 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 1240696
Gene end: 1242554
  
Corresponding Affymetrix probe sets: 205683_x_at (Human Genome U133 Plus 2.0 Array)   207134_x_at (Human Genome U133 Plus 2.0 Array)   207741_x_at (Human Genome U133 Plus 2.0 Array)   210084_x_at (Human Genome U133 Plus 2.0 Array)   215382_x_at (Human Genome U133 Plus 2.0 Array)   216474_x_at (Human Genome U133 Plus 2.0 Array)   216485_s_at (Human Genome U133 Plus 2.0 Array)   217023_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418247
Ensembl peptide - ENSP00000456821
Ensembl peptide - ENSP00000343577
NCBI entrez gene - 7177     See in Manteia.
OMIM - 191080
RefSeq - NM_003294
RefSeq Peptide - NP_003285
swissprot - A0A0C4DGM1
swissprot - J3QTS8
swissprot - Q15661
Ensembl - ENSG00000172236
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Tpsab1ENSMUSG00000024173Mus musculus
 Tpsb2ENSMUSG00000033825Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPSB2 / P20231 / tryptase beta 2 (gene/pseudogene)ENSG0000019725399
TPSD1 / Q9BZJ3 / tryptase delta 1ENSG0000009591773
PRSS50 / Q9UI38 / serine protease 50ENSG0000020654933
PRSS50 / Q9UI38 / serine protease 50ENSG0000028370633
PRSS40A / serine protease 40AENSG0000018329217
PRSS40B / serine protease 40BENSG0000018476115


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0022617 extracellular matrix disassembly IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172236 Q15661 / TPSAB1 / tryptase alpha/beta 1  / complex






 

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