ENSMUSG00000033825


Mus musculus

Features
Gene ID: ENSMUSG00000033825
  
Biological name :Tpsb2
  
Synonyms : Tpsb2
  
Possible biological names infered from orthology : P20231 / Q15661 / Q9BZJ3 / TPSAB1 / TPSD1 / tryptase alpha/beta 1 / tryptase beta 2 (gene/pseudogene) / tryptase delta 1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 25366550
Gene end: 25368094
  
Corresponding Affymetrix probe sets: 10442786 (MoGene1.0st)   1422180_a_at (Mouse Genome 430 2.0 Array)   1451802_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063499
NCBI entrez gene - 17229     See in Manteia.
MGI - MGI:96942
RefSeq - NM_010781
RefSeq - XM_006523740
RefSeq Peptide - NP_034911
swissprot - E9QJW9
Ensembl - ENSMUSG00000033825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q15661ENSG00000172236Homo sapiens
 TPSB2ENSG00000197253Homo sapiens
 TPSD1ENSG00000095917Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpsab1 / tryptase alpha/beta 1 / TPSB2* / TPSD1* / Q15661* / P20231* / Q9BZJ3* / tryptase delta 1* / tryptase beta 2 (gene/pseudogene)*ENSMUSG0000002417369
Prss34 / protease, serine 34ENSMUSG0000005639950
Prss29ENSMUSG0000003403948
Prss28ENSMUSG0000002417144
Prss46 / Q5M8S2 / Serine protease 46 ENSMUSG0000004971934
Prss50 / Q8BLH5 / Probable threonine protease PRSS50 / Q9UI38* / serine protease 50*ENSMUSG0000004875233


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esrrbtm1.1Nat/Esrrbtm1.2Nat,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

Allelic Composition: Tpsab1m1/Tpsab1m1,Tpsb2tm1(cre)Adch/Tpsb2tm1(cre)Adch
Genetic Background: B6.Cg-Tpsb2tm1(cre)Adch Tpsab1m1

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

 MP:0005462 abnormal mast cell morphology/development "anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

Allelic Composition: Tpsab1m1/Tpsab1m1,Tpsb2tm1(cre)Adch/Tpsb2tm1(cre)Adch
Genetic Background: B6.Cg-Tpsb2tm1(cre)Adch Tpsab1m1

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033825 Tpsb2 / TPSD1* / Q9BZJ3* / TPSAB1* / P20231* / Q15661* / tryptase delta 1* / tryptase alpha/beta 1* / tryptase beta 2 (gene/pseudogene)*  / complex






 

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