ENSMUSG00000024253


Mus musculus

Features
Gene ID: ENSMUSG00000024253
  
Biological name :Dync2li1
  
Synonyms : Cytoplasmic dynein 2 light intermediate chain 1 / Dync2li1 / Q8K0T2
  
Possible biological names infered from orthology : dynein cytoplasmic 2 light intermediate chain 1 / Q8TCX1
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 84626496
Gene end: 84655558
  
Corresponding Affymetrix probe sets: 10447224 (MoGene1.0st)   1428446_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025101
NCBI entrez gene - 213575     See in Manteia.
MGI - MGI:1913996
RefSeq - NM_172256
RefSeq Peptide - NP_758460
swissprot - Q8K0T2
Ensembl - ENSMUSG00000024253
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dync2li1ENSDARG00000039770Danio rerio
 DYNC2LI1ENSGALG00000009954Gallus gallus
 Q8TCX1ENSG00000138036Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022780  Dynein family light intermediate chain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0035721 intraciliary retrograde transport IBA
 biological_processGO:0035735 intraciliary transport involved in cilium assembly IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1902017 regulation of cilium assembly IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005868 cytoplasmic dynein complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0030990 intraciliary transport particle IDA
 cellular_componentGO:0031514 motile cilium IDA
 cellular_componentGO:0035869 ciliary transition zone IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0008569 ATP-dependent microtubule motor activity, minus-end-directed IEA
 molecular_functionGO:0045504 dynein heavy chain binding IEA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002825 abnormal notochord "malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0004131 abnormal embryonic ciliary morphology "any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0004132 absent embryonic cilia "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0006281 abnormal tail development "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0008926 abnormal anterior definitive endoderm morphology "any structural anomaly of the mesendoderm which first migrates from the node and which gives rise to the gut" [PMID:12464432]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0011998 decreased embryonic cilium length "reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0030538 abnormal notochordal plate morphology "any structural anomaly of the dorsal part of the notochordal process when the ventral portion breaks down; it is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube; the folding off of the notochordal plate gives rise to the notochord" [UBERON:0006267]
Show

Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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