ENSMUSG00000024517


Mus musculus

Features
Gene ID: ENSMUSG00000024517
  
Biological name :Grp
  
Synonyms : Gastrin-releasing peptide Neuromedin-C / Grp / Q8R1I2
  
Possible biological names infered from orthology : gastrin releasing peptide / P07492
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 65872820
Gene end: 65886579
  
Corresponding Affymetrix probe sets: 10456353 (MoGene1.0st)   1424525_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025395
Ensembl peptide - ENSMUSP00000133437
Ensembl peptide - ENSMUSP00000139014
NCBI entrez gene - 225642     See in Manteia.
MGI - MGI:95833
RefSeq - XM_006525887
RefSeq - NM_175012
RefSeq - XM_006525886
RefSeq Peptide - NP_778177
swissprot - V9GX72
swissprot - Q8R1I2
Ensembl - ENSMUSG00000024517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRPENSGALG00000040959Gallus gallus
 GRPENSG00000134443Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000874  Bombesin/neuromedin-B/ranatensin peptide family
 IPR015674  Gastrin releasing peptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007218 neuropeptide signaling pathway ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0036343 psychomotor behavior IMP
 biological_processGO:0043207 response to external biotic stimulus IMP
 biological_processGO:0090277 positive regulation of peptide hormone secretion ISS
 biological_processGO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen ISS
 molecular_functionGO:0005184 neuropeptide hormone activity ISO


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001440 abnormal grooming behavior "defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019865 Nmbr / O54799 / Neuromedin-B receptor / P28336*  / complex / reaction
 ENSMUSG00000031364 Grpr / P21729 / Gastrin-releasing peptide receptor / P30550*  / complex / reaction






 

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