ENSMUSG00000024533


Mus musculus

Features
Gene ID: ENSMUSG00000024533
  
Biological name :Spire1
  
Synonyms : 1 / Q52KF3 / Spire1
  
Possible biological names infered from orthology : Q08AE8 / spire type actin nucleation factor 1
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E1
Gene start: 67488209
Gene end: 67610790
  
Corresponding Affymetrix probe sets: 10459552 (MoGene1.0st)   1446117_at (Mouse Genome 430 2.0 Array)   1454962_at (Mouse Genome 430 2.0 Array)   1455409_at (Mouse Genome 430 2.0 Array)   1458203_at (Mouse Genome 430 2.0 Array)   1459548_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153692
Ensembl peptide - ENSMUSP00000080871
Ensembl peptide - ENSMUSP00000110702
Ensembl peptide - ENSMUSP00000153492
Ensembl peptide - ENSMUSP00000049336
NCBI entrez gene - 68166     See in Manteia.
MGI - MGI:1915416
RefSeq - XM_006526209
RefSeq - NM_194355
RefSeq - XM_006526203
RefSeq - XM_006526204
RefSeq - XM_006526205
RefSeq - XM_006526206
RefSeq - XM_006526207
RefSeq - NM_176832
RefSeq Peptide - NP_789802
RefSeq Peptide - NP_919336
swissprot - D3YTL8
swissprot - A0A286YE32
swissprot - Q52KF3
swissprot - A0A286YDN9
Ensembl - ENSMUSG00000024533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q1LYM3ENSDARG00000035868Danio rerio
 spire1bENSDARG00000038445Danio rerio
 ENSGALG00000034052Gallus gallus
 ENSGALG00000013817Gallus gallus
 Q08AE8ENSG00000134278Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Q8K1S6 / Spire2 / Q8WWL2* / spire type actin nucleation factor 2*ENSMUSG0000001015436


Protein motifs (from Interpro)
Interpro ID Name
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011019  KIND domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR029901  Protein Spire
 IPR029905  Protein Spire1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0036089 cleavage furrow formation IMP
 biological_processGO:0040038 polar body extrusion after meiotic divisions IMP
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0046907 intracellular transport IMP
 biological_processGO:0048193 Golgi vesicle transport IDA
 biological_processGO:0051295 establishment of meiotic spindle localization IMP
 biological_processGO:0060996 dendritic spine development IMP
 biological_processGO:0070649 formin-nucleated actin cable assembly IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003779 actin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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