ENSMUSG00000024803


Mus musculus

Features
Gene ID: ENSMUSG00000024803
  
Biological name :Ankrd1
  
Synonyms : Ankrd1 / Ankyrin repeat domain-containing protein 1 / Q9CR42
  
Possible biological names infered from orthology : ankyrin repeat domain 1 / Q15327
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C2
Gene start: 36111965
Gene end: 36119844
  
Corresponding Affymetrix probe sets: 10467191 (MoGene1.0st)   1420991_at (Mouse Genome 430 2.0 Array)   1420992_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025718
NCBI entrez gene - 107765     See in Manteia.
MGI - MGI:1097717
RefSeq - NM_013468
RefSeq Peptide - NP_038496
swissprot - Q9CR42
Ensembl - ENSMUSG00000024803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ankrd1aENSDARG00000075263Danio rerio
 ankrd1bENSDARG00000076192Danio rerio
 ANKRD1ENSGALG00000006491Gallus gallus
 ANKRD1ENSG00000148677Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ankrd2 / Q9WV06 / Ankyrin repeat domain-containing protein 2 / Q9GZV1* / ankyrin repeat domain 2*ENSMUSG0000002517241
Q812A3 / Ankrd23 / Ankyrin repeat domain-containing protein 23 / Q86SG2* / ankyrin repeat domain 23*ENSMUSG0000006765341
Ankef1 / Q9D2J7 / Ankyrin repeat and EF-hand domain-containing protein 1 / Q9NU02* / ankyrin repeat and EF-hand domain containing 1*ENSMUSG0000007477121
Q91WK7 / Ankrd54 / Ankyrin repeat domain-containing protein 54 / Q6NXT1* / ankyrin repeat domain 54*ENSMUSG0000003305520
Psmd10 / Q9Z2X2 / proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 / O75832* / proteasome 26S subunit, non-ATPase 10*ENSMUSG0000003142919
Gm42417 / Q86SG2* / ANKRD23* / ankyrin repeat domain 23*ENSMUSG0000010951018
Asb8 / ankyrin repeat and SOCS box containing 8 / Q9H765*ENSMUSG0000004817517


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045445 myoblast differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0031674 I band IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0031432 titin binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0061629 RNA polymerase II sequence-specific DNA-binding transcription factor binding IBA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001220 epidermal necrosis "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ankrd1tm1.1Jmda/Ankrd1tm1.1Jmda
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2afvTg(Wnt1-cre)11Rth/0,Wnt5atm1Amc/Wnt5atm1.1Krvl
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

Allelic Composition: Ankrd1tm1.1Jmda/Ankrd1tm1.1Jmda
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Ankrd1tm1.1Jmda/Ankrd1tm1.1Jmda
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1tm1.2Jmda
Genetic Background: B6.129S6(Cg)-Ankrd1tm1.2Jmda

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0012688 abnormal heart ventricles weight "abnormal average weight of both the left and right ventricles together" [MPD:Molly]
Show

Allelic Composition: Ankrd1tm1.1Jmda/Ankrd1tm1.1Jmda
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ankrd1tm1.2Jmda/Ankrd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr