ENSMUSG00000025172


Mus musculus

Features
Gene ID: ENSMUSG00000025172
  
Biological name :Ankrd2
  
Synonyms : Ankrd2 / Ankyrin repeat domain-containing protein 2 / Q9WV06
  
Possible biological names infered from orthology : ankyrin repeat domain 2 / Q9GZV1
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 42036038
Gene end: 42045110
  
Corresponding Affymetrix probe sets: 10463189 (MoGene1.0st)   1419621_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026172
NCBI entrez gene - 56642     See in Manteia.
MGI - MGI:1861447
RefSeq - XM_017318264
RefSeq - NM_020033
RefSeq - XM_006527234
RefSeq Peptide - NP_064417
swissprot - Q9WV06
Ensembl - ENSMUSG00000025172
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ankrd2ENSDARG00000002722Danio rerio
 ANKRD2ENSGALG00000007539Gallus gallus
 ANKRD2ENSG00000165887Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ankrd1 / Q9CR42 / Ankyrin repeat domain-containing protein 1 / Q15327* / ankyrin repeat domain 1*ENSMUSG0000002480340
Q812A3 / Ankrd23 / Ankyrin repeat domain-containing protein 23 / Q86SG2* / ankyrin repeat domain 23*ENSMUSG0000006765335
Ankef1 / Q9D2J7 / Ankyrin repeat and EF-hand domain-containing protein 1 / Q9NU02* / ankyrin repeat and EF-hand domain containing 1*ENSMUSG0000007477123
Gm42417 / Q86SG2* / ANKRD23* / ankyrin repeat domain 23*ENSMUSG0000010951018
Q91WK7 / Ankrd54 / Ankyrin repeat domain-containing protein 54 / Q6NXT1* / ankyrin repeat domain 54*ENSMUSG0000003305518
Asb8 / ankyrin repeat and SOCS box containing 8 / Q9H765*ENSMUSG0000004817517
Psmd10 / Q9Z2X2 / proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 / O75832* / proteasome 26S subunit, non-ATPase 10*ENSMUSG0000003142917


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001817 regulation of cytokine production IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0010832 negative regulation of myotube differentiation IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0035994 response to muscle stretch TAS
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:2000291 regulation of myoblast proliferation IMP
 cellular_componentGO:0000791 euchromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030016 myofibril IDA
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0031674 I band IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003712 transcription coregulator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031432 titin binding IPI
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0061629 RNA polymerase II sequence-specific DNA-binding transcription factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: En1tm2(cre)Wrst/En1+,Tor1atm2Wtd/Tor1atm3.1Wtd
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J * SJL

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgk3fz-fy/Sgk3fz-fy
Genetic Background: involves: 101 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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