ENSMUSG00000031429


Mus musculus

Features
Gene ID: ENSMUSG00000031429
  
Biological name :Psmd10
  
Synonyms : proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 / Psmd10 / Q9Z2X2
  
Possible biological names infered from orthology : O75832 / proteasome 26S subunit, non-ATPase 10
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F1
Gene start: 140948429
Gene end: 140956728
  
Corresponding Affymetrix probe sets: 10607004 (MoGene1.0st)   1436559_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033805
Ensembl peptide - ENSMUSP00000108602
NCBI entrez gene - 53380     See in Manteia.
MGI - MGI:1858898
RefSeq - NM_001164177
RefSeq - NM_016883
RefSeq Peptide - NP_001157649
RefSeq Peptide - NP_058579
swissprot - Q9Z2X2
swissprot - A2AG83
Ensembl - ENSMUSG00000031429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd10ENSDARG00000015628Danio rerio
 PSMD10ENSGALG00000008287Gallus gallus
 O75832ENSG00000101843Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ankef1 / Q9D2J7 / Ankyrin repeat and EF-hand domain-containing protein 1 / Q9NU02* / ankyrin repeat and EF-hand domain containing 1*ENSMUSG0000007477128
Asb8 / ankyrin repeat and SOCS box containing 8 / Q9H765*ENSMUSG0000004817527
Q812A3 / Ankrd23 / Ankyrin repeat domain-containing protein 23 / Q86SG2* / ankyrin repeat domain 23*ENSMUSG0000006765326
Ankrd1 / Q9CR42 / Ankyrin repeat domain-containing protein 1 / Q15327* / ankyrin repeat domain 1*ENSMUSG0000002480326
Ankrd2 / Q9WV06 / Ankyrin repeat domain-containing protein 2 / Q9GZV1* / ankyrin repeat domain 2*ENSMUSG0000002517225
Q91WK7 / Ankrd54 / Ankyrin repeat domain-containing protein 54 / Q6NXT1* / ankyrin repeat domain 54*ENSMUSG0000003305520
Gm42417 / Q86SG2* / ANKRD23* / ankyrin repeat domain 23*ENSMUSG0000010951016


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007253 cytoplasmic sequestering of NF-kappaB IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0070682 proteasome regulatory particle assembly IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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