ENSG00000101843


Homo sapiens

Features
Gene ID: ENSG00000101843
  
Biological name :PSMD10
  
Synonyms : O75832 / proteasome 26S subunit, non-ATPase 10 / PSMD10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q22.3
Gene start: 108084207
Gene end: 108091618
  
Corresponding Affymetrix probe sets: 1554577_a_at (Human Genome U133 Plus 2.0 Array)   219485_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345963
Ensembl peptide - ENSP00000361370
Ensembl peptide - ENSP00000361369
Ensembl peptide - ENSP00000354906
Ensembl peptide - ENSP00000217958
NCBI entrez gene - 5716     See in Manteia.
OMIM - 300880
RefSeq - NM_170750
RefSeq - NM_002814
RefSeq Peptide - NP_002805
RefSeq Peptide - NP_736606
swissprot - O75832
swissprot - B1AJY6
swissprot - B1AJY5
swissprot - B1AJY7
Ensembl - ENSG00000101843
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmd10ENSDARG00000015628Danio rerio
 PSMD10ENSGALG00000008287Gallus gallus
 Psmd10ENSMUSG00000031429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86SG2 / ANKRD23 / ankyrin repeat domain 23ENSG0000016312628
ANKRD1 / Q15327 / ankyrin repeat domain 1ENSG0000014867728
ANKEF1 / Q9NU02 / ankyrin repeat and EF-hand domain containing 1ENSG0000013262328
ANKRD2 / Q9GZV1 / ankyrin repeat domain 2ENSG0000016588728
ASB8 / Q9H765 / ankyrin repeat and SOCS box containing 8ENSG0000017798127
Q6NXT1 / ANKRD54 / ankyrin repeat domain 54ENSG0000010012423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006521 regulation of cellular amino acid metabolic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007253 cytoplasmic sequestering of NF-kappaB IDA
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070682 proteasome regulatory particle assembly IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway TAS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation TAS
 cellular_componentGO:0000502 proteasome complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005838 proteasome regulatory particle TAS
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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