ENSMUSG00000024831


Mus musculus

Features
Gene ID: ENSMUSG00000024831
  
Biological name :Ighmbp2
  
Synonyms : Ighmbp2 / immunoglobulin mu binding protein 2
  
Possible biological names infered from orthology : P38935
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 3260924
Gene end: 3283017
  
Corresponding Affymetrix probe sets: 10464452 (MoGene1.0st)   1421016_at (Mouse Genome 430 2.0 Array)   1441825_x_at (Mouse Genome 430 2.0 Array)   1450091_at (Mouse Genome 430 2.0 Array)   1450092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025751
Ensembl peptide - ENSMUSP00000122827
Ensembl peptide - ENSMUSP00000113438
NCBI entrez gene - 20589     See in Manteia.
MGI - MGI:99954
RefSeq - NM_009212
RefSeq - XM_006531702
RefSeq Peptide - NP_033238
swissprot - D3Z5P5
swissprot - A0A0B4J1E3
swissprot - D6RFT3
Ensembl - ENSMUSG00000024831
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ighmbp2ENSDARG00000069274Danio rerio
 IGHMBP2ENSGALG00000004328Gallus gallus
 P38935ENSG00000132740Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zgrf1 / Q0VGT4 / zinc finger, GRF-type containing 1 / Q86YA3*ENSMUSG000000512788


Protein motifs (from Interpro)
Interpro ID Name
 IPR000058  Zinc finger, AN1-type
 IPR001374  R3H domain
 IPR003593  AAA+ ATPase domain
 IPR004483  Helicase SMUBP-2/Hcs1-like
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR034072  DNA-binding protein SMUBP-2, R3H domain
 IPR035896  AN1-like Zinc finger
 IPR036867  R3H domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0051260 protein homooligomerization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008186 RNA-dependent ATPase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0032575 ATP-dependent 5"-3" RNA helicase activity IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0043141 ATP-dependent 5"-3" DNA helicase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd/Ighmbp2nmd
Genetic Background: CBA/J

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd/Ighmbp2nmd
Genetic Background: CBA/J

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Cmn1CAST/Ei/?,Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Cmn2CAST/Ei/?,Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Cmn3CAST/Ei/?,Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Cmn3C57BL/6J/?,Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Chrm1tm1Stl/Chrm1+
Genetic Background: C57BL/6-Chrm1tm1Stl

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0003158 dysphagia "difficulty in swallowing food or liquid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003901 abnormal PQ interval "anomaly in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004235 abnormal masseter muscle morphology "any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0004239 abnormal temporalis muscle morphology "any structural anomaly of the superior-most masticatory muscle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf5go-Y/Fgf5go-Y
Genetic Background: C57BL/Lac

 MP:0004545 enlarged esophagus "increased size of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Ttn-Ighmbp2)108Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)90Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,MnmC/MnmC
Genetic Background: involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic Background: B6.BKS-Ighmbp2nmd-2J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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