ENSMUSG00000024846


Mus musculus

Features
Gene ID: ENSMUSG00000024846
  
Biological name :Cst6
  
Synonyms : Cst6 / cystatin E/M
  
Possible biological names infered from orthology : Q15828
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 5344705
Gene end: 5349574
  
Corresponding Affymetrix probe sets: 10464999 (MoGene1.0st)   1427910_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025764
NCBI entrez gene - 73720     See in Manteia.
MGI - MGI:1920970
RefSeq - NM_028623
RefSeq Peptide - NP_082899
swissprot - Q9D1B1
Ensembl - ENSMUSG00000024846
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cst3ENSDARG00000007795Danio rerio
 zgc:163030ENSDARG00000069192Danio rerio
 CST6ENSG00000175315Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cst3 / P21460 / Cystatin-C / P01034*ENSMUSG0000002744732
Cst10 / Q9JM84 / Cystatin 10 / CST1* / CST2* / CST4* / CST5* / P01037* / P09228* / P28325* / P01036* / cystatin D* / cystatin S* / cystatin SN* / cystatin SA*ENSMUSG0000003315630
Cst7 / O89098 / Cystatin-F / O76096*ENSMUSG0000006812926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR027214  Cystatin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IBA
 cellular_componentGO:0001533 cornified envelope IDA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0002020 protease binding IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0012725 small sebaceous gland "decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]
Show

Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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