ENSMUSG00000027447


Mus musculus

Features
Gene ID: ENSMUSG00000027447
  
Biological name :Cst3
  
Synonyms : Cst3 / Cystatin-C / P21460
  
Possible biological names infered from orthology : P01034
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: G3
Gene start: 148871722
Gene end: 148875692
  
Corresponding Affymetrix probe sets: 10488415 (MoGene1.0st)   1426195_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117672
Ensembl peptide - ENSMUSP00000028938
NCBI entrez gene - 13010     See in Manteia.
MGI - MGI:102519
RefSeq - NM_009976
RefSeq Peptide - NP_034106
swissprot - A2APX3
swissprot - P21460
Ensembl - ENSMUSG00000027447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cst3ENSDARG00000007795Danio rerio
 zgc:163030ENSDARG00000069192Danio rerio
 CST3ENSGALG00000028520Gallus gallus
 CST3ENSG00000101439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cst10 / Q9JM84 / Cystatin 10 / CST1* / CST2* / CST4* / CST5* / P01037* / P09228* / P28325* / P01036* / cystatin D* / cystatin S* / cystatin SN* / cystatin SA*ENSMUSG0000003315641
Cst6 / cystatin E/M / Q15828*ENSMUSG0000002484634
Cst7 / O89098 / Cystatin-F / O76096*ENSMUSG0000006812927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR018073  Proteinase inhibitor I25, cystatin, conserved site
 IPR027214  Cystatin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007431 salivary gland development IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010711 negative regulation of collagen catabolic process IEA
 biological_processGO:0010716 negative regulation of extracellular matrix disassembly IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034103 regulation of tissue remodeling IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042747 circadian sleep/wake cycle, REM sleep IEA
 biological_processGO:0043067 regulation of programmed cell death IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0060009 Sertoli cell development IEA
 biological_processGO:0060311 negative regulation of elastin catabolic process IEA
 biological_processGO:0060313 negative regulation of blood vessel remodeling IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0097435 supramolecular fiber organization IEA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IBA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043292 contractile fiber IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Neutrophil degranulation
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb2tm1.1Wij/Crb2tm1.1Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Crb2tm1.1Wij/Crb2tm1.1Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb2tm1.1Wij/Crb2tm1.1Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb2tm1.1Wij/Crb2tm1.1Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb2tm1.1Wij/Crb2tm1.1Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009862 abnormal aorta elastic tissue morphology "any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cst3tm1Karl/Cst3tm1Karl
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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