ENSMUSG00000025007


Mus musculus

Features
Gene ID: ENSMUSG00000025007
  
Biological name :Aldh18a1
  
Synonyms : Aldh18a1 / Delta-1-pyrroline-5-carboxylate synthase Glutamate 5-kinase Gamma-glutamyl phosphate reductase / Q9Z110
  
Possible biological names infered from orthology : aldehyde dehydrogenase 18 family member A1 / P54886
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 40550257
Gene end: 40588463
  
Corresponding Affymetrix probe sets: 10467470 (MoGene1.0st)   1415836_at (Mouse Genome 430 2.0 Array)   1435855_x_at (Mouse Genome 430 2.0 Array)   1437325_x_at (Mouse Genome 430 2.0 Array)   1437333_x_at (Mouse Genome 430 2.0 Array)   1437620_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025979
Ensembl peptide - ENSMUSP00000135417
Ensembl peptide - ENSMUSP00000115429
Ensembl peptide - ENSMUSP00000135759
Ensembl peptide - ENSMUSP00000135426
Ensembl peptide - ENSMUSP00000135419
NCBI entrez gene - 56454     See in Manteia.
MGI - MGI:1888908
RefSeq - NM_153554
RefSeq - NM_019698
RefSeq Peptide - NP_705782
RefSeq Peptide - NP_062672
swissprot - Q9Z110
swissprot - D3Z0B4
swissprot - H3BKJ8
swissprot - H3BKK0
swissprot - H3BLE8
Ensembl - ENSMUSG00000025007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aldh18a1ENSDARG00000099579Danio rerio
 ENSGALG00000034655Gallus gallus
 P54886ENSG00000059573Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000965  GPR domain
 IPR001048  Aspartate/glutamate/uridylate kinase
 IPR001057  Glutamate/acetylglutamate kinase
 IPR005715  Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase
 IPR005766  Delta l-pyrroline-5-carboxylate synthetase
 IPR015590  Aldehyde dehydrogenase domain
 IPR016161  Aldehyde/histidinol dehydrogenase
 IPR016162  Aldehyde dehydrogenase, N-terminal
 IPR019797  Glutamate 5-kinase, conserved site
 IPR020593  Gamma-glutamyl phosphate reductase GPR, conserved site
 IPR036393  Acetylglutamate kinase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006536 glutamate metabolic process IEA
 biological_processGO:0006561 proline biosynthetic process IEA
 biological_processGO:0006592 ornithine biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019240 citrulline biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055129 L-proline biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004349 glutamate 5-kinase activity ISO
 molecular_functionGO:0004350 glutamate-5-semialdehyde dehydrogenase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017084 delta1-pyrroline-5-carboxylate synthetase activity ISO
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025007 Q9Z110 / Aldh18a1 / Delta-1-pyrroline-5-carboxylate synthase Glutamate 5-kinase Gamma-glutamyl phosphate reductase / P54886* / aldehyde dehydrogenase 18 family member A1*  / complex






 

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