ENSMUSG00000025209


Mus musculus

Features
Gene ID: ENSMUSG00000025209
  
Biological name :Twnk
  
Synonyms : Q8CIW5 / twinkle mtDNA helicase / Twnk
  
Possible biological names infered from orthology : Q96RR1
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 45006558
Gene end: 45012762
  
Corresponding Affymetrix probe sets: 10463448 (MoGene1.0st)   1434168_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026227
NCBI entrez gene - 226153     See in Manteia.
MGI - MGI:2137410
RefSeq - NM_153796
RefSeq - XM_006527003
RefSeq Peptide - NP_722491
swissprot - Q8CIW5
Ensembl - ENSMUSG00000025209
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 twnkENSDARG00000099900Danio rerio
 TWNKENSGALG00000017627Gallus gallus
 TWNKENSG00000107815Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007694  DNA helicase, DnaB-like, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR034154  Archaeal primase DnaG/twinkle, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006264 mitochondrial DNA replication IEA
 biological_processGO:0006268 DNA unwinding involved in DNA replication IDA
 biological_processGO:0006390 mitochondrial transcription IEA
 biological_processGO:0034214 protein hexamerization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0042645 mitochondrial nucleoid ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003678 DNA helicase activity ISA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043139 5"-3" DNA helicase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Bcl11atm1Mbu/Bcl11atm1Mbu,Klf1tm1Nimr/Klf1+,Eportm1(EGFP/cre)Uk/Epor+,Tg(HBB)8.1Gvs/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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