ENSMUSG00000025375


Mus musculus

Features
Gene ID: ENSMUSG00000025375
  
Biological name :Aatk
  
Synonyms : Aatk / apoptosis associated tyrosine kinase
  
Possible biological names infered from orthology : Q6ZMQ8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120007313
Gene end: 120047167
  
Corresponding Affymetrix probe sets: 10393668 (MoGene1.0st)   10393685 (MoGene1.0st)   1416936_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099309
Ensembl peptide - ENSMUSP00000067181
Ensembl peptide - ENSMUSP00000099308
NCBI entrez gene - 11302     See in Manteia.
MGI - MGI:1197518
RefSeq - XM_006531994
RefSeq - NM_001198787
RefSeq - NM_007377
RefSeq - XM_006531991
RefSeq - XM_006531992
RefSeq - XM_006531993
RefSeq - NM_001198785
RefSeq Peptide - NP_001185716
RefSeq Peptide - NP_031403
RefSeq Peptide - NP_001185714
swissprot - B1AZF9
swissprot - B1AZF3
Ensembl - ENSMUSG00000025375
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aatkaENSDARG00000078222Danio rerio
 aatkbENSDARG00000104442Danio rerio
 AATKENSGALG00000006901Gallus gallus
 AATKENSG00000181409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lmtk3 / lemur tyrosine kinase 3 / Q96Q04*ENSMUSG0000006204432
Lmtk2 / Q3TYD6 / Serine/threonine-protein kinase LMTK2 / Q8IWU2* / lemur tyrosine kinase 2*ENSMUSG0000003897031


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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