ENSMUSG00000038970


Mus musculus

Features
Gene ID: ENSMUSG00000038970
  
Biological name :Lmtk2
  
Synonyms : Lmtk2 / Q3TYD6 / Serine/threonine-protein kinase LMTK2
  
Possible biological names infered from orthology : lemur tyrosine kinase 2 / Q8IWU2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 144100436
Gene end: 144188204
  
Corresponding Affymetrix probe sets: 10527306 (MoGene1.0st)   1455018_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048238
NCBI entrez gene - 231876     See in Manteia.
MGI - MGI:3036247
RefSeq - NM_001081109
RefSeq - XM_006504825
RefSeq Peptide - NP_001074578
swissprot - Q3TYD6
Ensembl - ENSMUSG00000038970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmtk2ENSDARG00000076324Danio rerio
 si:dkey-40m6.8ENSDARG00000029114Danio rerio
 LMTK2ENSGALG00000003479Gallus gallus
 LMTK2ENSG00000164715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aatk / apoptosis associated tyrosine kinase / Q6ZMQ8*ENSMUSG0000002537529
Lmtk3 / lemur tyrosine kinase 3 / Q96Q04*ENSMUSG0000006204425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001881 receptor recycling IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007399 nervous system development ISO
 biological_processGO:0007411 axon guidance ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0033572 transferrin transport IEA
 biological_processGO:0045022 early endosome to late endosome transport IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0070853 myosin VI binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Spry2tm1Ayos/Spry2tm1Ayos,Spry4tm1Ayos/Spry4tm1Ayos
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr