ENSMUSG00000025428


Mus musculus

Features
Gene ID: ENSMUSG00000025428
  
Biological name :Atp5a1
  
Synonyms : Atp5a1 / ATP synthase subunit alpha, mitochondrial / Q03265
  
Possible biological names infered from orthology : ATP5F1A / ATP synthase F1 subunit alpha / P25705
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E3
Gene start: 77773729
Gene end: 77782869
  
Corresponding Affymetrix probe sets: 10456891 (MoGene1.0st)   1420037_at (Mouse Genome 430 2.0 Array)   1423111_at (Mouse Genome 430 2.0 Array)   1449710_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026495
Ensembl peptide - ENSMUSP00000120436
Ensembl peptide - ENSMUSP00000110396
NCBI entrez gene - 11946     See in Manteia.
MGI - MGI:88115
RefSeq - NM_007505
RefSeq Peptide - NP_031531
swissprot - D6RJ16
swissprot - D3Z6F5
swissprot - Q03265
Ensembl - ENSMUSG00000025428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atp5fa1ENSDARG00000010149Danio rerio
 ENSGALG00000043758Gallus gallus
 ENSGALG00000037880Gallus gallus
 P25705ENSG00000152234Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000194  ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
 IPR000793  ATP synthase, alpha subunit, C-terminal
 IPR004100  ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
 IPR005294  ATP synthase, F1 complex, alpha subunit
 IPR020003  ATPase, alpha/beta subunit, nucleotide-binding domain, active site
 IPR023366  ATP synthase subunit alpha, N-terminal domain-like superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033732  ATP synthase, F1 complex, alpha subunit nucleotide-binding domain
 IPR036121  ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006754 ATP biosynthetic process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0015986 ATP synthesis coupled proton transport IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0099132 ATP hydrolysis coupled cation transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005753 mitochondrial proton-transporting ATP synthase complex IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045259 proton-transporting ATP synthase complex IEA
 cellular_componentGO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0032559 adenyl ribonucleotide binding IEA
 molecular_functionGO:0042288 MHC class I protein binding IEA
 molecular_functionGO:0043532 angiostatin binding IEA
 molecular_functionGO:0046933 proton-transporting ATP synthase activity, rotational mechanism IEA


Pathways (from Reactome)
Pathway description
Formation of ATP by chemiosmotic coupling
Cristae formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fosbtm1Meg/Fosb+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

Allelic Composition: ApcMin/Apc+,Atp5a1Mom2/Atp5a1+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Braftm1Mmcm/Braftm1Mmcm,Nkx3-1tm4(cre/ERT2)Mms/Nkx3-1+,Ptentm1Hwu/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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