ENSMUSG00000025429


Mus musculus

Features
Gene ID: ENSMUSG00000025429
  
Biological name :Pstpip2
  
Synonyms : Proline-serine-threonine phosphatase-interacting protein 2 / Pstpip2 / Q99M15
  
Possible biological names infered from orthology : Q9H939
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E3
Gene start: 77794545
Gene end: 77882007
  
Corresponding Affymetrix probe sets: 10456904 (MoGene1.0st)   1421410_a_at (Mouse Genome 430 2.0 Array)   1421411_at (Mouse Genome 430 2.0 Array)   1455405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110389
NCBI entrez gene - 19201     See in Manteia.
MGI - MGI:1335088
RefSeq - NM_013831
RefSeq Peptide - NP_038859
swissprot - Q99M15
Ensembl - ENSMUSG00000025429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pstpip2ENSDARG00000089569Danio rerio
 PSTPIP2ENSGALG00000040136Gallus gallus
 Q9H939ENSG00000152229Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pstpip1 / proline-serine-threonine phosphatase interacting protein 1 / O43586*ENSMUSG0000003232242
Gas7 / growth arrest-specific protein 7 isoform d / O60861* / growth arrest specific 7*ENSMUSG0000003306616


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR027267  AH/BAR domain superfamily
 IPR030106  Proline-serine-threonine phosphatase-interacting protein 2
 IPR031160  F-BAR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0016477 cell migration IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003779 actin binding NAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000019 thick ears "increased width of the epidermal and cartilaginous tissue that makes up the ear" [J:65045]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0000316 cellular necrosis "pathologic death of cells, usually from irreversible damage" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0000573 enlarged hind paws "larger than average size of the rear feet" [J:51296]
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Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0000580 deformed nails "atypical shape or size of the nails" [J:45400]
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Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2Arge/Brca1tm2Arge
Genetic Background: involves: 129

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca1tm2Arge/Brca1tm2Arge
Genetic Background: involves: 129

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Brca1tm2Arge/Brca1tm2Arge
Genetic Background: involves: 129

 MP:0001849 ear inflammation "local accumulation of fluid, plasma proteins and leukocytes in the ear" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca1tm2Arge/Brca1tm2Arge
Genetic Background: involves: 129

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

Allelic Composition: Pstpip2Lupo/Pstpip2Lupo,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0005190 osteomyelitis "bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Pstpip2m1Bcs/Pstpip2m1Bcs
Genetic Background: involves: C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdcscid
Genetic Background: NOD.CB17-Prkdcscid

 MP:0030422 abnormal outer ear cartilage morphology "any structural anomaly of the elastic cartilage components of the auricles and/or external acoustic meatus" [MGI:anna]
Show

Allelic Composition: Pstpip2cmo/Pstpip2cmo
Genetic Background: C.Cg-Pstpip2cmo/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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