ENSMUSG00000025485


Mus musculus

Features
Gene ID: ENSMUSG00000025485
  
Biological name :Ric8a
  
Synonyms : Q3TIR3 / Ric8a / Synembryn-A
  
Possible biological names infered from orthology : Q9NPQ8 / RIC8 guanine nucleotide exchange factor A
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F4
Gene start: 140856957
Gene end: 140864372
  
Corresponding Affymetrix probe sets: 10558707 (MoGene1.0st)   1424819_a_at (Mouse Genome 430 2.0 Array)   1438949_at (Mouse Genome 430 2.0 Array)   1438950_x_at (Mouse Genome 430 2.0 Array)   1455809_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026558
Ensembl peptide - ENSMUSP00000147952
Ensembl peptide - ENSMUSP00000147773
NCBI entrez gene - 101489     See in Manteia.
MGI - MGI:2141866
RefSeq - NM_053194
RefSeq Peptide - NP_444424
swissprot - A0A1B0GSI8
swissprot - A0A1B0GS30
swissprot - Q3TIR3
Ensembl - ENSMUSG00000025485
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ric8aENSDARG00000007247Danio rerio
 RIC8AENSGALG00000004191Gallus gallus
 RIC8AENSG00000177963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ric8b / Q80XE1 / Synembryn-B / Q9NVN3* / RIC8 guanine nucleotide exchange factor B*ENSMUSG0000003562046


Protein motifs (from Interpro)
Interpro ID Name
 IPR008376  Synembryn
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR019318  Guanine nucleotide exchange factor, Ric8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway ISO
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070586 cell-cell adhesion involved in gastrulation IMP
 biological_processGO:0071711 basement membrane organization IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008914 enlarged cerebellum "increased size of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009268 absent cerebellum fissure "absence of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010387 abnormal Bergmann glial cell morphology "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pycardtm1Ayaz/Pycardtm1Ayaz,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ric8atm1.1Zhua/Ric8atm1.1Zhua,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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