ENSMUSG00000035620


Mus musculus

Features
Gene ID: ENSMUSG00000035620
  
Biological name :Ric8b
  
Synonyms : Q80XE1 / Ric8b / Synembryn-B
  
Possible biological names infered from orthology : Q9NVN3 / RIC8 guanine nucleotide exchange factor B
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 84917616
Gene end: 85018337
  
Corresponding Affymetrix probe sets: 10365408 (MoGene1.0st)   1435096_at (Mouse Genome 430 2.0 Array)   1439724_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046981
Ensembl peptide - ENSMUSP00000093032
Ensembl peptide - ENSMUSP00000148897
NCBI entrez gene - 237422     See in Manteia.
MGI - MGI:2682307
RefSeq - XM_006513625
RefSeq - NM_001013441
RefSeq - NM_183172
RefSeq Peptide - NP_001013459
RefSeq Peptide - NP_898995
swissprot - Q80XE1
swissprot - A0A1L1SQ47
Ensembl - ENSMUSG00000035620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ric8bENSDARG00000005972Danio rerio
 RIC8BENSGALG00000029484Gallus gallus
 RIC8BENSG00000111785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ric8a / Q3TIR3 / Synembryn-A / Q9NPQ8* / RIC8 guanine nucleotide exchange factor A*ENSMUSG0000002548543


Protein motifs (from Interpro)
Interpro ID Name
 IPR008376  Synembryn
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR019318  Guanine nucleotide exchange factor, Ric8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005938 cell cortex IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0011677 abnormal olfactory sensory neuron physiology "any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals" [MGI:csmith]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0012020 abnormal olfactory epithelium physiology "any functional anomaly in the epithelial cells that line the interior of the nose" [MGI:smb]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0020348 decreased olfactory sensory neuron number "decreased number of the neurons in the olfactory epithelium that are activated by specific odorants" [MGI:mberry, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Omptm4(cre)Mom/Omp+,Ric8btm1c(EUCOMM)Hmgu/Ric8btm1c(EUCOMM)Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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