| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0000367 | abnormal coat/ hair morphology | "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0000380 | small hair follicles | "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0000711 | thymic cortex hypoplasia | "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0001221 | epidermal atrophy | "wasting of the epidermal layer of the skin" [J:65033] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0001243 | abnormal dermal layer morphology | "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0002942 | decreased circulating alanine transaminase level | "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0003957 | abnormal nitric oxide homeostasis | "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cdx2tm1Fbe/Cdx2tm2.1Fbe
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/cJ
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn
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| MP:0005309 | increased circulating ammonia level | "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263] |
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn
Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005311 | abnormal circulating amino acid level | "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263] |
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn
Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005449 | abnormal food intake | "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn
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| MP:0005558 | decreased creatinine clearance | "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn
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| MP:0005591 | decreased vasodilation | "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0005632 | decreased circulating aspartate transaminase level | "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006143 | increased diastolic blood pressure | "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006144 | increased systolic blood pressure | "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006263 | decreased diastolic blood pressure | "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006264 | decreased systolic blood pressure | "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0008476 | increased spleen red pulp amount | "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0008482 | decreased spleen germinal center number | "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0010177 | acanthocytosis | "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn
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