ENSMUSG00000025608


Mus musculus

Features
Gene ID: ENSMUSG00000025608
  
Biological name :Podxl
  
Synonyms : podocalyxin-like / Podxl / Q9R0M4
  
Possible biological names infered from orthology : O00592
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 31519488
Gene end: 31563981
  
Corresponding Affymetrix probe sets: 10543791 (MoGene1.0st)   1417396_at (Mouse Genome 430 2.0 Array)   1448688_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026698
NCBI entrez gene - 27205     See in Manteia.
MGI - MGI:1351317
RefSeq - NM_013723
RefSeq Peptide - NP_038751
swissprot - Q791G4
swissprot - Q9R0M4
Ensembl - ENSMUSG00000025608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 podxlENSDARG00000031228Danio rerio
 PODXLENSGALG00000006409Gallus gallus
 PODXLENSG00000128567Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013836  CD34/Podocalyxin
 IPR017403  Podocalyxin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007162 negative regulation of cell adhesion ISS
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0022407 regulation of cell-cell adhesion IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IMP
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0032534 regulation of microvillus assembly IDA
 biological_processGO:0033634 positive regulation of cell-cell adhesion mediated by integrin ISS
 biological_processGO:0050900 leukocyte migration IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development ISS
 biological_processGO:0072175 epithelial tube formation ISS
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0031528 microvillus membrane IDA
 cellular_componentGO:0036057 slit diaphragm ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irf7m1Btlr/Irf7+
Genetic Background: C57BL/6J-Irf7m1Btlr

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Podxltm1Kmn/Podxl+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlsHsd * C57BL/6)

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008061 absent podocyte slit diaphragm "absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0008138 absent podocyte foot process "absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0011136 increased lung endothelial cell adhesion "increased ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment" [MGI:csmith]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0011137 decreased lung endothelial cell adhesion "decreased ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment" [MGI:csmith]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011641 abnormal pulmonary collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
Show

Allelic Composition: Trex1tm1.1Fwpe/Trex1+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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