| MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
|
| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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| MP:0000270 | abnormal heart tube morphology | "malformed embryonic heart " [J:37888] |
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000285 | abnormal cardiac valve morphology | "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000286 | abnormal mitral valve morphology | "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000288 | abnormal pericardium morphology | "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tln1tm4.1Crit/Tln1tm4.1Crit,Tg(Pf4-icre)Q3Rsko/?
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0000530 | abnormal kidney vasculature | "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0000534 | abnormal ureter morphology | "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Magel2tm1.1Mus/Magel2+
Genetic Background: B6.129S2-Magel2tm1.1Mus
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0000662 | abnormal branching of the mammary ductal tree | "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Atf4tm1Kry/Atf4tm1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6J * FVB
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| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0000693 | spleen hyperplasia | "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0000717 | abnormal lymphocyte number | "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0000752 | dystrophic muscle | "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994] |
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Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Y
Genetic Background: involves: 129 * A/J * C57BL/6
Allelic Composition: Dysfprmd/Dysfprmd,Hprttm2(CAG-Myof)Isrd/Hprttm2(CAG-Myof)Isrd
Genetic Background: involves: 129 * A/J * C57BL/6
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm2(UAS-Bmp4)Bhr/Hprt+,Tg(Wnt1-GAL4)1Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Porcntm1.2Vdv/Porcn+
Genetic Background: involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J * FVB/N
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| MP:0000947 | convulsive seizures | "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0000959 | abnormal somatic sensory system morphology | |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia,Hprttm1(CMV-cre)Brd/Hprt+,Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv * 129S/SvEvBrd
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| MP:0000961 | abnormal dorsal root ganglia morphology | "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0000964 | small dorsal root ganglia | "reduced size of the dorsal root ganglia" [J:17123] |
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Allelic Composition: EdaTa-26H/Eda+
Genetic Background: Not Specified
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| MP:0001008 | abnormal sympathetic ganglia morphology | "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0001364 | decreased anxiety-related response | "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043] |
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Hprttm2Detl/Hprttm2Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Hprttm4Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Hprttm6Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Y
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
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| MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0001417 | decreased exploration in new environment | "less amount of time spent investigating a new location" [J:79870] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001426 | polydipsia | "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0001441 | increased grooming behavior | "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
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| MP:0001458 | abnormal object recognition memory | "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0001501 | abnormal sleep pattern | "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Whrnwi/Whrnwi
Genetic Background: involves: STOCK a Tyrp1b Myo5ad Oca2p Ednrbs
Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0001545 | abnormal hematopoietic system physiology | "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Rab27am1Anu/Rab27am1Anu
Genetic Background: C57BL/6JAnu-Rab27am1Anu
Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0001596 | hypotension | "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001613 | abnormal vasodilation | "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1(H1-RNAi:Tmsb4x)Prri/Hprt+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
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Allelic Composition: Hprttm1(H1-RNAi:Tmsb4x)Prri/Hprt+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: CpR435X/CpR435X,Hfetm1Sly/Hfetm1Sly
Genetic Background: involves: C3H/DiSnA * C57BL/10ScSnA
Allelic Composition: Hprttm1(UBC-UBB)Rrk/Y,Ubctm1Rrk/Ubctm1Rrk
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0001762 | polyuria | "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0001792 | impaired wound healing | "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ywhaetm1Awb/Ywhae+
Genetic Background: involves: 129S6/SvEvTac
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| MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Rettm2.1Cos/Rettm2.1Cos
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Hprttm1(CAG-Tgfbr1*)Lba/Y,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2
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| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0001883 | mammary adenocarcinoma | "higher than normal incidence of malignant tumors of the mammary gland" [J:62919] |
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Allelic Composition: Atf4tm1Kry/Atf4tm1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6J * FVB
Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep
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| MP:0001899 | absent long term depression | "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm2(UAS-Bmp4)Bhr/Hprt+,Tg(Wnt1-GAL4)1Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm1(H1-RNAi:Tmsb4x)Prri/Hprt+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0001961 | abnormal reflex | "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hprttm4Detl/Hprttm4Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002027 | lung adenocarcinoma | "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002036 | rhabdomyosarcoma | "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002047 | hepatic hemangioma | "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0002048 | lung adenoma | "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002063 | abnormal learning/memory/conditioning | "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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| MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Hprttm2Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Hprttm4Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Hprttm6Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Hprttm2Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Hprttm4Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Hprttm6Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*)#Rgab/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Hprttm2Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Hprttm4Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Hprttm6Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002095 | abnormal skin pigmentation | "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: EdaTa-26H/Eda+
Genetic Background: Not Specified
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm
Genetic Background: involves: 129S1/Sv
Allelic Composition: Hprttm1(ACTB-Epor)Unc/Hprttm1(ACTB-Epor)Unc
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dhcr7tm1Fdp/Dhcr7tm2Fdp
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic Background: BKSW.129X1-Atp2b4tm1Ges
Allelic Composition: Hprttm1.1Pobe/?
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm1Isrd/Y
Genetic Background: involves: C57BL/6
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Hprttm1(Nfkb1-EGFP)Cjo/Hprt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hprttm1(Nfkb1-EGFP)Cjo/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pbsn*-cre/ERT2)Jir/Hprt+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor
Allelic Composition: Hprttm4(Ple88-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm4(Ple88-EGFP)Ems/Mmjax
Allelic Composition: Hprttm7(Ple185-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm7(Ple185-EGFP)Ems/Mmjax
Allelic Composition: Hprttm8(Ple151-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm8(Ple151-EGFP)Ems/Mmjax
Allelic Composition: Hprttm9(Ple178-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems
Allelic Composition: Hprttm11(Ple176-EGFP/cre)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm10(Ple162-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems
Allelic Composition: Hprttm12(Ple177-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems
Allelic Composition: Hprttm13(Ple54-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm13(Ple54-EGFP)Ems/Mmjax
Allelic Composition: Hprttm14(Ple103-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm14(Ple103-EGFP/cre)Ems
Allelic Composition: Hprttm15(Ple111-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm15(Ple111-EGFP)Ems/Mmjax
Allelic Composition: Hprttm16(Ple167-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems
Allelic Composition: Hprttm18(Ple90-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm18(Ple90-EGFP)Ems/Mmjax
Allelic Composition: Hprttm17(Ple48-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm17(Ple48-lacZ)Ems/Mmjax
Allelic Composition: Hprttm31(Ple67-EGFP)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm20(Ple53-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm20(Ple53-EGFP)Ems/Mmjax
Allelic Composition: Hprttm32(Ple112-EGFP)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm33(Ple183-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm33(Ple183-EGFP)Ems/Mmjax
Allelic Composition: Hprttm37(lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm44(Ple49-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm44(Ple49-lacZ)Ems/Mmjax
Allelic Composition: Hprttm34(Ple186-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm34(Ple186-EGFP)Ems/Mmjax
Allelic Composition: Hprttm54(Ple233-EGFP)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm54(Ple233-EGFP)Ems/Mmjax
Allelic Composition: Hprttm41(Ple160-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm41(Ple160-lacZ)Ems/Mmjax
Allelic Composition: Hprttm42(Ple131-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm42(Ple131-lacZ)Ems/Mmjax
Allelic Composition: Hprttm45(Ple67-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm45(Ple67-lacZ)Ems/Mmjax
Allelic Composition: Hprttm50(Ple55-lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm63(Ple12-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm63(Ple12-lacZ)Ems/Mmjax
Allelic Composition: Hprttm64(Ple170-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm64(Ple170-lacZ)Ems/Mmjax
Allelic Composition: Hprttm65(Ple53-lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm66(Ple5-lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm19(Ple88-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm19(Ple88-lacZ)Ems/Mmjax
Allelic Composition: Hprttm38(Ple17-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm38(Ple17-lacZ)Ems/Mmjax
Allelic Composition: Hprttm39(Ple24-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm39(Ple24-lacZ)Ems/Mmjax
Allelic Composition: Hprttm40(Ple34-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm40(Ple34-lacZ)Ems/Mmjax
Allelic Composition: Hprttm43(Ple140-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm43(Ple140-lacZ)Ems/Mmjax
Allelic Composition: Hprttm56(Ple25-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm56(Ple25-lacZ)Ems/Mmjax
Allelic Composition: Hprttm58(Ple119-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm58(Ple119-lacZ)Ems/Mmjax
Allelic Composition: Hprttm59(Ple123-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm59(Ple123-lacZ)Ems/Mmjax
Allelic Composition: Hprttm62(Ple153-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm62(Ple153-lacZ)Ems/Mmjax
Allelic Composition: Hprttm67(Ple238-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm67(Ple238-lacZ)Ems/Mmjax
Allelic Composition: Hprttm68(Ple127-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm68(Ple127-lacZ)Ems/Mmjax
Allelic Composition: Hprttm69(Ple134-lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm70(Ple240-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm70(Ple240-lacZ)Ems/Mmjax
Allelic Composition: Hprttm71(Ple155-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm71(Ple155-lacZ)Ems/Mmjax
Allelic Composition: Hprttm72(Ple158-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm72(Ple158-lacZ)Ems/Mmjax
Allelic Composition: Hprttm73(Ple142-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm73(Ple142-lacZ)Ems/Mmjax
Allelic Composition: Hprttm53(CAG-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm53(CAG-lacZ)Ems/Mmjax
Allelic Composition: Hprttm74(Ple232-lacZ)Ems/Y
Genetic Background: B6.129P2(Cg)-Hprttm74(Ple232-lacZ)Ems/Mmjax
Allelic Composition: Hprttm57(Ple26-lacZ)Ems/Y
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm5(Myh7-GFP,Myh6-CFP)Unc/Y
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Hprttm75(Ple143-lacZ)Ems/Y
Genetic Background: B6.Cg-Hprttm75(Ple143-lacZ)Ems/Mmjax
Allelic Composition: Hprttm331a(Ple275-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm331a(Ple275-icre/ERT2)Ems
Allelic Composition: Hprttm332(Ple272-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm332(Ple272-icre/ERT2)Ems
Allelic Composition: Hprttm333(Ple281-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm333(Ple281-icre/ERT2)Ems
Allelic Composition: Hprttm334a(Ple279-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm334a(Ple279-icre/ERT2)Ems
Allelic Composition: Hprttm335(Ple277-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm335(Ple277-icre/ERT2)Ems
Allelic Composition: Hprttm336a(Ple134-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm336a(Ple134-icre/ERT2)Ems
Allelic Composition: Hprttm337a(Ple285-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm337a(Ple285-icre/ERT2)Ems
Allelic Composition: Hprttm338a(Ple284-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm338a(Ple284-icre/ERT2)Ems
Allelic Composition: Hprttm339a(Ple280-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm339a(Ple280-icre/ERT2)Ems
Allelic Composition: Hprttm340(Ple252-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm340(Ple252-icre/ERT2)Ems
Allelic Composition: Hprttm341a(Ple273-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm341a(Ple273-icre/ERT2)Ems
Allelic Composition: Hprttm342a(Ple282-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm342a(Ple282-icre/ERT2)Ems
Allelic Composition: Hprttm343(Ple270-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm343(Ple270-icre/ERT2)Ems
Allelic Composition: Hprttm344a(Ple5-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm344a(Ple5-icre/ERT2)Ems
Allelic Composition: Hprttm345a(icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm345a(icre/ERT2)Ems
Allelic Composition: Hprttm346a(Ple264-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm346a(Ple264-icre/ERT2)Ems
Allelic Composition: Hprttm347a(Ple155-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm347a(Ple155-icre/ERT2)Ems
Allelic Composition: Hprttm348a(Ple265-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm348a(Ple265-icre/ERT2)Ems
Allelic Composition: Hprttm349a(hs671-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm349a(hs671-icre/ERT2)Ems
Allelic Composition: Hprttm350a(Ple232-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm350a(Ple232-icre/ERT2)Ems
Allelic Composition: Hprttm351a(Ple198-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm351a(Ple198-icre/ERT2)Ems
Allelic Composition: Hprttm352a(Hspa1a-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm352a(Hspa1a-icre/ERT2)Ems
Allelic Composition: Hprttm2(CMV-tdTomato)Nat/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hprttm1(CMV-GFP)Nat/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hprttm353(Ple274-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm353(Ple274-icre/ERT2)Ems
Allelic Composition: Hprttm354(Ple283-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm354(Ple283-icre/ERT2)Ems
Allelic Composition: Hprttm355(Ple286-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm355(Ple286-icre/ERT2)Ems
Allelic Composition: Hprttm356a(Ple271-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm356a(Ple271-icre/ERT2)Ems
Allelic Composition: Hprttm357(Ple278-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm357(Ple278-icre/ERT2)Ems
Allelic Composition: Hprttm358(Ple287-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm358(Ple287-icre/ERT2)Ems
Allelic Composition: Hprttm359a(Ple94-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm359a(Ple94-icre/ERT2)Ems
Allelic Composition: Hprttm360a(Ple253-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm360a(Ple253-icre/ERT2)Ems
Allelic Composition: Hprttm361a(Ple267-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm361a(Ple267-icre/ERT2)Ems
Allelic Composition: Hprttm362a(Ple304-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm362a(Ple304-icre/ERT2)Ems
Allelic Composition: Hprttm363a(hs1218-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm363a(hs1218-icre/ERT2)Ems
Allelic Composition: Hprttm364a(CAGGS-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm364a(CAGGS-icre/ERT2)Ems
Allelic Composition: Hprttm365a(Ple266-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm365a(Ple266-icre/ERT2)Ems
Allelic Composition: Hprttm366a(Ple67-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm366a(Ple67-icre/ERT2)Ems
Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems
Allelic Composition: Hprttm1.1(CAG-DLL1*,-Venus)Gos/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1
Allelic Composition: Hprttm1.1(CAG-DLL1*,-Venus)Gos/Hprttm1.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1
Allelic Composition: Hprttm2.1(CAG-DLL1*,-Venus)Gos/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1
Allelic Composition: Hprttm2.1(CAG-DLL1*,-Venus)Gos/Hprttm2.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1
Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1
Allelic Composition: Hprttm3.1(CAG-DLL1*,-Venus)Gos/Hprttm3.1(CAG-DLL1*,-Venus)Gos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1
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| MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002207 | abnormal long term potentiation | "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0002272 | abnormal nervous system electrophysiology | "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Pvalbtm1(cre)Arbr/Pvalb+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002357 | abnormal spleen white pulp morphology | "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0002396 | abnormal hematopoietic system morphology/development | "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Impdh1tm1Bmi/Impdh1tm1Bmi,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002404 | intestinal adenoma | "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: ApcMin/Apc+,Gpa33tm1(GNAS)Wtsi/Gpa33+,Hprttm1(CMV-cre)Brd/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
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| MP:0002413 | abnormal megakaryoblast morphology/development | "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0002575 | increased circulating ketone body level | "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
Allelic Composition: Arnttm1Bra/Arnttm1Bra,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0002731 | megacolon | "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722] |
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002738 | hyperresponsive to tactile stimuli | "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0002741 | small olfactory bulb | "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871] |
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Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
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| MP:0002747 | abnormal aortic valve morphology | "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprtb-m1/Y
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0002800 | abnormal short-term recognition memory | "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm2(AGT)Sig/Hprttm2(AGT)Sig,Tg(hAGT)2041Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL/J
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| MP:0002842 | increased blood pressure | "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(AGT)Sig/Hprttm2(AGT)Sig,Tg(hAGT)2041Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL/J
Allelic Composition: Hprttm2(AGT)Sig/Hprttm2(AGT)Sig
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Hprttm2(AGT)Sig/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0002872 | polycythemia | "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Y
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg
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| MP:0002882 | abnormal neuron | "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Hprttm1(CAG-Gys1*)Jjg/?,Tg(Nes-cre)1Kag/?
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac
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| MP:0002906 | susceptibility to pharmacologically induced seizures | "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504] |
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0002920 | reduced paired-pulse facilitation | "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002925 | abnormal cardiovascular development | "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0002947 | hemangioma | "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0002962 | increased protein excretion | "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Hprttm1(tetO-EGFP/Rac1*)Shaw/Y,Tg(NPHS2-rtTA2*M2)1Jbk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Hprttm1(tetO-EGFP/Rac1*)Shaw/Y,Tg(Nphs1-rtTA*3G)8Jhm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002969 | impaired social transmission of food preference | "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218] |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0002988 | decreased urine osmolarity | "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000] |
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003025 | increased vascular smooth muscle contraction | "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems
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| MP:0003057 | abnormal epicardium morphology | "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0003058 | increased insulin secretion | "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0003171 | phenotypic reversion | "reverse mutation to wild-type phenotype from a previously characterized mutant phenotype" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Plxna1tm1Kik/Plxna1tm1Kik
Genetic Background: Not Specified
Allelic Composition: Hprttm1Dwm/Hprtb-m3
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003205 | testicular atrophy | "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0003228 | abnormal sinus venosus | "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0003243 | abnormal dopaminergic neuron morphology | "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
Allelic Composition: Hprtb-m3/Hprtb-m3
Genetic Background: B6.129P2-Hprtb-m3
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| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv
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| MP:0003339 | decreased number of pancreatic beta cells | "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0003350 | increased circulating levels of thyroid hormone | |
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Allelic Composition: Thrbtm1Mkni/Thrbtm1Mkni,Hprttm1(TG-cre)1Sasr/Y
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0003360 | depression-related behavior | |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
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| MP:0003384 | abnormal ventral body wall | "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Porcntm1.2Vdv/Porcn+
Genetic Background: involves: 129S4/SvJaeSor * 129S5/SvEvBrd * C57BL/6J * FVB/N
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| MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0003544 | abnormal vascular endothelial cell migration | "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387] |
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Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems
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| MP:0003562 | abnormal beta cell physiology | "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0003632 | abnormal nervous system morphology | |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0003667 | hemangiosarcoma | "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0003935 | abnormal craniofacial development | "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0003957 | abnormal nitric oxide homeostasis | "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm2(UAS-Bmp4)Bhr/Hprt+,Tg(Wnt1-GAL4)1Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Hprttm1(CAG-cre)Mnn/Hprt+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
Allelic Composition: Porcntm1.1Vdv/Porcn+,Hprttm1(CAG-cre)Mnn/Hprt+
Genetic Background: involves: 129S/Sv * C57BL/6J
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| MP:0003985 | renal fibrosis | "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0004003 | abnormal vascular endothelial cell physiology | "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems
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| MP:0004042 | decreased susceptibility to kidney reperfusion injury | "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Ighmtm1Cgn/Ighmtm1Cgn,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S2/SvPas * C57BL * SJL
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| MP:0004073 | caudal body truncation | "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Porcntm1.1Vdv/Porcn+,Hprttm1(CAG-cre)Mnn/Hprt+
Genetic Background: involves: 129S/Sv * C57BL/6J
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| MP:0004084 | abnormal cardiac muscle relaxation | "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0004110 | transposition of great arteries | "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004113 | abnormal aortic arch morphology | "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004160 | retroesophageal right subclavian artery | "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0004191 | neuronal intranuclear inclusions | "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Hprttm2Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Hprttm4Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Hprttm6Detl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm2Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm4Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm6Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0004494 | abnormal synaptic glutamate release | "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm10Sia/Otx2tm10Sia
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
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| MP:0004843 | abnormal Paneth cell morphology | "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0004883 | abnormal blood vessel healing | "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems
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| MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Slc17a6tm1.1Thna/Slc17a6tm1.1Thna
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
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| MP:0004994 | abnormal brain wave pattern | "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0005076 | abnormal cell differentiation | "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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| MP:0005078 | abnormal cytotoxic T cell physiology | "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprtb-m3/Y,Impdh2tm1Bmi/Impdh2+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005079 | defective cytotoxic T cell cytolysis | "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692] |
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005095 | decreased T cell proliferation | "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005119 | decreased circulating thyroid-stimulating hormone level | "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N
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| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005166 | decreased susceptiblity to injury | "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hprttm1(Pck1-cre)Vhh/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Allelic Composition: Hprttm1(ACTB-Opa1)Lsc/Y
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hprttm1(Ins2-HBEGF)Herr/Y,Tg(Ins2-cre/ERT)1Dam/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0005244 | hemopericardium | "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Hprttm1(H1-RNAi:Tmsb4x)Prri/Hprt+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0005280 | abnormal fatty acid level | "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1
Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Hprttm6(CAG-Fat1)Geno/Hprttm6(CAG-Fat1)Geno
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
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| MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0005319 | abnormal enzyme/ coenzyme level | "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
Allelic Composition: Hprttm2(AGT)Asku/Y,Tg(REN)64071Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005424 | jerky movement | "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Hoxd10tm1Mrc/Hoxd10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0005468 | abnormal thyroid hormone level | "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp,Tg(Myog-cre)1Eno/0
Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N
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| MP:0005470 | increased thyroxine level | "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Thrbtm1Mkni/Thrbtm1Mkni,Hprttm1(TG-cre)1Sasr/Y
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0005477 | increased circulating thyroxine level | "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Thrbtm1Mkni/Thrbtm1Mkni,Hprttm1(TG-cre)1Sasr/Y
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0005505 | increased platelet count | "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005528 | decreased glomerular filtration rate | "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae
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| MP:0005564 | increased hemoglobin content | "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0005583 | decreased renin activity | "less than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Hprttm1Dhm/Hprttm1Dhm
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm1Dhm/Hprttm1Dhm,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
Allelic Composition: Hprttm1Dhm/Y,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas
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| MP:0005642 | decreased mean corpuscular hemoglobin concentration | "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0005643 | decreased dopamine level | "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298] |
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
Allelic Composition: Hprtb-m1/Y
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv
Allelic Composition: Hprtb-m3/Hprtb-m3
Genetic Background: B6.129P2-Hprtb-m3
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Hprttm1(ACTB-Opa1)Lsc/Y
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0006056 | increased vascular endothelial cell number | "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Hprttm1(Pck1-cre)Vhh/Y,Vhltm1Jae/Vhltm1Jae
Genetic Background: involves: 129 * BALB/c * C57BL/6
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| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0006128 | pulmonary valve stenosis | "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0006144 | increased systolic blood pressure | "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
Allelic Composition: Hprttm2(AGT)Asku/Y,Tg(REN)64071Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0006264 | decreased systolic blood pressure | "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae
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| MP:0006283 | medulloblastoma | "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0006373 | abnormal circulating angiotensinogen level | "anomaly in the concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
Allelic Composition: Hprttm2(AGT)Asku/Y,Tg(REN)64071Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008060 | abnormal podocyte slit diaphragm morphology | "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0008061 | absent podocyte slit diaphragm | "absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
Allelic Composition: Hprttm1(tetO-EGFP/Rac1*)Shaw/Y,Tg(NPHS2-rtTA2*M2)1Jbk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0008254 | increased megakaryocyte cell number | "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac
Allelic Composition: Hprttm1(CAG-Gys1*)Jjg/?,Tg(Nes-cre)1Kag/?
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm2(CAG-Ppp1r3c)Jjg/?,Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac
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| MP:0008301 | adrenal medulla hyperplasia | "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0008414 | abnormal spatial reference memory | "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0008428 | abnormal spatial working memory | "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm1(CAG-Glra3*)Jcme/Y,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0008469 | abnormal protein level | "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pomgnt1tm1Stk/Pomgnt1tm1Stk
Genetic Background: involves: 129S/SvEv
Allelic Composition: Hprttm2(AGT)Asku/Y,Tg(REN)64071Sig/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0008540 | abnormal cerebrum morphology | "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287] |
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Allelic Composition: Hprttm86(NR2E1,bEMS223)Ems/Y,Nr2e1frc/Nr2e1frc
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
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| MP:0008700 | decreased interleukin-4 secretion | "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008826 | abnormal splenic cell ratio | "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0008872 | abnormal response to xenobiotics | "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
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| MP:0008883 | abnormal enterocyte proliferation | "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0008884 | abnormal enterocyte apoptosis | "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(Ubc-BCL3)Sbn/Gt(ROSA)26Sor+,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6
Allelic Composition: Hprttm1(CAG-NRIP1)Vcls/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0009113 | increased pancreatic beta cell mass | "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0009114 | decreased pancreatic beta cell mass | "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Ins2-HBEGF)Herr/Y
Genetic Background: involves: 129 * C57BL/6
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| MP:0009179 | abnormal pancreatic alpha cell differentiation | "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065] |
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Hprttm1(Ins2-HBEGF)Herr/Y,Tg(Ins2-cre/ERT)1Dam/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
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| MP:0009219 | prostate intraepithelial neoplasia | "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009220 | prostate adenocarcinoma | "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(Pbsn*-cre/ERT2)Jir/Y,Ptentm2Mak/Ptentm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009335 | decreased splenocyte proliferation | "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009436 | fragmentation of sleep/wake states | "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384] |
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Allelic Composition: Hprttm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt+,Tg(PSEN1)5Dbo/0
Genetic Background: involves: 129P2/OlaHsd
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| MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0009704 | skin squamous cell carcinoma | "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0009845 | abnormal neural crest cell morphology | "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
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| MP:0010108 | abnormal renal water reabsorption | "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd
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| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atf4tm1Kry/Atf4tm1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6J * FVB
Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep
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| MP:0010373 | myeloid hyperplasia | "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptger4tm1.2Matb/Ptger4+
Genetic Background: B6.129S6-Ptger4tm1.2Matb
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0010449 | heart right ventricle outflow tract stenosis | "abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0010556 | thin ventricle myocardium compact layer | "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Hprttm1(tetO-Runx1,-EGFP)Enk/Hprt+,Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hprttm3(CAG-Tbx18,-Venus)Akis/Y,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/SvImJ * NMRI
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Hprttm1(UBC-UBB)Rrk/Hprttm1(UBC-UBB)Rrk,Ubctm1Rrk/Ubctm1Rrk
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Hprttm1(UBC-UBB)Rrk/Y,Ubctm1Rrk/Ubctm1Rrk
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Hprttm1(CAG-cre)Mnn/Hprttm1(CAG-cre)Mnn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Porcntm1.1Vdv/Porcn+,Hprttm1(CAG-cre)Mnn/Hprt+
Genetic Background: involves: 129S/Sv * C57BL/6J
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Ext1tm1.2Vcs/Ext1tm1.2Vcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Hprttm1(CAG-cre)Mnn/Hprt+,Ptpn11tm1Ckq/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Vegfatm1Pec/Vegfatm1Pec
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Hprttm2(UAS-Bmp4)Bhr/Hprt+,Tg(Wnt1-GAL4)1Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Porcntm1.1Vdv/Porcn+,Hprttm1(CAG-cre)Mnn/Hprt+
Genetic Background: involves: 129S/Sv * C57BL/6J
Allelic Composition: Hprttm1(H1-RNAi:Tmsb4x)Prri/Hprt+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Hprttm1(H1-RNAi:Tmsb4x)Prri/Hprt+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL
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| MP:0011262 | abnormal branchial arch mesenchyme morphology | "any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Y,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Allelic Composition: Hprttm2(Pgk1-Pac/TK)Brd/Hprt+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
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| MP:0011353 | expanded mesangial matrix | "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0011395 | decreased fetal cardiomyocyte proliferation | "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith] |
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Allelic Composition: Hprttm4(CAG-Tbx18*,-Venus)Akis/Y,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,Tbx18tm4(cre)Akis/Tbx18+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
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| MP:0011426 | abnormal ureter smooth muscle morphology | "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna] |
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Allelic Composition: Magel2tm1.1Mus/Magel2+
Genetic Background: B6.129S2-Magel2tm1.1Mus
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| MP:0011427 | mesangial cell hyperplasia | "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna] |
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N
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| MP:0011620 | abnormal habituation to a new environment | "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith] |
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Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Y
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
Allelic Composition: Hprttm5(Camk2a-BACE1)Geno/Hprttm5(Camk2a-BACE1)Geno
Genetic Background: B6.129P2-Hprttm5(Camk2a-BACE1)Geno
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| MP:0011635 | abnormal mitochondrial crista morphology | "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061] |
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Allelic Composition: Hprttm1(ACTB-Opa1)Lsc/Y
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J
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| MP:0012232 | abnormal ceramide level | |
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Allelic Composition: Cntn1usl/Cntn1usl
Genetic Background: MRL/MpJ-Faslpr Cntn1usl/GrsrJ
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Hprt+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+,Hprttm1(sb-Onco-Array)Peli/Y
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0012592 | decreased brain choline acetyltransferase activity | "reduced ability of the brain to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA" [GO:0004102, http://orcid.org/0000-0001-5208-3432] |
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
Allelic Composition: Hprtb-m3/Hprtb-m3
Genetic Background: B6.129P2-Hprtb-m3
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| MP:0020078 | decreased brain tyrosine 3-monooxygenase activity | "reduction in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain" [GOC:NV, http://en.wikipedia.org/wiki/Tyrosine_hydroxylase] |
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Allelic Composition: ApcMin/Apc+,Dnmt3btm1Jae/Dnmt3btm1Jae,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * FVB/N
Allelic Composition: Hprtb-m3/Hprtb-m3
Genetic Background: B6.129P2-Hprtb-m3
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| MP:0020168 | decreased thyroid gland weight | "lower than average weight of the thyroid gland" [GOC:NV] |
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Allelic Composition: Thrbtm1Mkni/Thrbtm1Mkni,Hprttm1(TG-cre)1Sasr/Y
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Thrbtm1Mkni/Thrb+,Hprttm1(TG-cre)1Sasr/Y
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0020316 | decreased vascular endothelial cell proliferation | "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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