ENSMUSG00000025873


Mus musculus

Features
Gene ID: ENSMUSG00000025873
  
Biological name :Faf2
  
Synonyms : Faf2 / FAS-associated factor 2 / Q3TDN2
  
Possible biological names infered from orthology : Fas associated factor family member 2 / Q96CS3
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 54621784
Gene end: 54664063
  
Corresponding Affymetrix probe sets: 10405291 (MoGene1.0st)   1428422_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117945
Ensembl peptide - ENSMUSP00000123026
Ensembl peptide - ENSMUSP00000121606
Ensembl peptide - ENSMUSP00000121182
Ensembl peptide - ENSMUSP00000120594
Ensembl peptide - ENSMUSP00000026991
Ensembl peptide - ENSMUSP00000116612
NCBI entrez gene - 76577     See in Manteia.
MGI - MGI:1923827
RefSeq - XM_017315634
RefSeq - NM_178397
RefSeq - XM_006517452
RefSeq - XM_011244582
RefSeq - XM_011244583
RefSeq Peptide - NP_848484
swissprot - Q3TDN2
swissprot - D6RE51
swissprot - D3YUP4
swissprot - F6XLD9
swissprot - D3Z4G9
swissprot - D3Z2H4
Ensembl - ENSMUSG00000025873
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faf2ENSDARG00000052374Danio rerio
 FAF2ENSGALG00000003331Gallus gallus
 FAF2ENSG00000113194Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Faf1 / P54731 / FAS-associated factor 1 / Q9UNN5*ENSMUSG0000001051728


Protein motifs (from Interpro)
Interpro ID Name
 IPR001012  UBX domain
 IPR006577  UAS
 IPR009060  UBA-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0030970 retrograde protein transport, ER to cytosol ISO
 biological_processGO:0034389 lipid particle organization ISO
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0035473 lipase binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISO
 molecular_functionGO:0055102 lipase inhibitor activity ISO


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Id4tm1Vdr/Id4+,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0003980 increased circulating phospholipid level "greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0003981 decreased circulating phospholipid level "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

 MP:0010331 abnormal apolipoprotein level "anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Faf2tm1Tfji/Faf2tm1Tfji,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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