ENSMUSG00000010517


Mus musculus

Features
Gene ID: ENSMUSG00000010517
  
Biological name :Faf1
  
Synonyms : Faf1 / FAS-associated factor 1 / P54731
  
Possible biological names infered from orthology : Q9UNN5
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 109676588
Gene end: 109963960
  
Corresponding Affymetrix probe sets: 10506989 (MoGene1.0st)   1418242_at (Mouse Genome 430 2.0 Array)   1434370_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099785
NCBI entrez gene - 14084     See in Manteia.
MGI - MGI:109419
RefSeq - NM_007983
RefSeq Peptide - NP_032009
swissprot - P54731
Ensembl - ENSMUSG00000010517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faf1ENSDARG00000022418Danio rerio
 FAF1ENSGALG00000010536Gallus gallus
 FAF1ENSG00000185104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Faf2 / Q3TDN2 / FAS-associated factor 2 / Q96CS3* / Fas associated factor family member 2*ENSMUSG0000002587319


Protein motifs (from Interpro)
Interpro ID Name
 IPR001012  UBX domain
 IPR006577  UAS
 IPR029071  Ubiquitin-like domain superfamily
 IPR033043  FAS-associated factor 1, UBX domain
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007253 cytoplasmic sequestering of NF-kappaB IEA
 biological_processGO:0008219 cell death ISO
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0031334 positive regulation of protein complex assembly IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dscam3J/Dscam3J
Genetic Background: involves: C3H/HeSnSmn * CB17

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dscam3J/Dscam3J
Genetic Background: involves: C3H/HeSnSmn * CB17

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Dscam3J/Dscam3J
Genetic Background: involves: C3H/HeSnSmn * CB17

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Otx2tm5(OTX2)Asim/Otx2tm5(OTX2)Asim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Dscam3J/Dscam3J
Genetic Background: involves: C3H/HeSnSmn * CB17

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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