ENSMUSG00000025900


Mus musculus

Features
Gene ID: ENSMUSG00000025900
  
Biological name :Rp1
  
Synonyms : Oxygen-regulated protein 1 / P56716 / Rp1
  
Possible biological names infered from orthology : P56715 / RP1, axonemal microtubule associated
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A1
Gene start: 3999557
Gene end: 4409241
  
Corresponding Affymetrix probe sets: 10352928 (MoGene1.0st)   1424963_at (Mouse Genome 430 2.0 Array)   1424964_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142146
Ensembl peptide - ENSMUSP00000146439
Ensembl peptide - ENSMUSP00000027032
NCBI entrez gene - 19888     See in Manteia.
MGI - MGI:1341105
RefSeq - NM_011283
RefSeq - XM_011238362
RefSeq - NM_001195662
RefSeq Peptide - NP_001182591
RefSeq Peptide - NP_035413
swissprot - A0A0A6YXU6
swissprot - P56716
swissprot - A0A140LHJ6
Ensembl - ENSMUSG00000025900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rp1ENSDARG00000077687Danio rerio
 RP1ENSG00000104237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rp1l1 / Q8CGM2 / retinitis pigmentosa 1 homolog like 1 / RP1 like 1*ENSMUSG0000004604913
Dcdc2a / Q5DU00 / Doublecortin domain-containing protein 2 / DCDC2* / Q9UHG0* / doublecortin domain containing 2*ENSMUSG000000359105
Dcdc2b / doublecortin domain containing 2B / A2VCK2*ENSMUSG000000785523
Dcdc2c / Q9D1B8 / Doublecortin domain-containing protein 2C / A8MYV0* / doublecortin domain containing 2C*ENSMUSG000000206331


Protein motifs (from Interpro)
Interpro ID Name
 IPR001024  PLAT/LH2 domain
 IPR003533  Doublecortin domain
 IPR008996  Cytokine IL1/FGF
 IPR033013  Oxygen-regulated protein 1
 IPR036392  PLAT/LH2 domain superfamily
 IPR036572  Doublecortin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007026 negative regulation of microtubule depolymerization TAS
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0035082 axoneme assembly IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035845 photoreceptor cell outer segment organization IDA
 biological_processGO:0042461 photoreceptor cell development IEA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0046548 retinal rod cell development IDA
 biological_processGO:0046549 retinal cone cell development IDA
 biological_processGO:0046785 microtubule polymerization TAS
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0071482 cellular response to light stimulus IMP
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1902857 positive regulation of non-motile cilium assembly IGI
 cellular_componentGO:0001750 photoreceptor outer segment IEA
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005875 microtubule associated complex IDA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097542 ciliary tip IDA
 molecular_functionGO:0004096 catalase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0020037 heme binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

Allelic Composition: Rp1tm1Eap/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Ren1tm1Tkh/Ren1tm1Tkh
Genetic Background: C57BL/6-Ren1tm1Tkh

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap,Tg(Rp1)L2Eap/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crxtvrm65/Crxtvrm65
Genetic Background: C57BL/6J-Crxtvrm65/J

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

Allelic Composition: Rp1tvrm64/Rp1tvrm64
Genetic Background: C57BL/6J-Rp1tvrm64/J

 MP:0003729 abnormal photoreceptor outer segments "malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

Allelic Composition: Rp1tm1Eap/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rp1tm1Jnz/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Rp1tm1Eap/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rp1tm1Jnz/Rp1+,Rp1l1tm1Jnz/Rp1l1+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

Allelic Composition: Rp1tm1Eap/Rp1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rp1tm1Eap/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rp1tm1Jnz/Rp1+,Rp1l1tm1Jnz/Rp1l1+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1tm1Jnz/Rp1+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap,Tg(Rp1)T1Eap/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap,Tg(Rp1)L2Eap/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Itpr3tf-Csh/Itpr3tf-Csh
Genetic Background: Not Specified

Allelic Composition: Rp1tm1Eap/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap,Tg(Rp1)T1Eap/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap,Tg(Rp1)L2Eap/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.Cg-Il4/Il13tm3Anjm

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rp1tvrm64/Rp1tvrm64
Genetic Background: C57BL/6J-Rp1tvrm64/J

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rp1tm1Eap/Rp1tm1Eap
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0008581 disorganized photoreceptor inner segment "derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rp1tvrm64/Rp1tvrm64
Genetic Background: C57BL/6J-Rp1tvrm64/J

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rp1tvrm64/Rp1tvrm64
Genetic Background: C57BL/6J-Rp1tvrm64/J

Allelic Composition: Rp1tm2.1Eap/Rp1tm2.1Eap,Tg(Rp1)L2Eap/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Rp1m1Jdun/Rp1m1Jdun
Genetic Background: C57BL/6-Rp1m1Jdun

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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