ENSMUSG00000025930


Mus musculus

Features
Gene ID: ENSMUSG00000025930
  
Biological name :Msc
  
Synonyms : Msc / Musculin / O88940
  
Possible biological names infered from orthology : O60682
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 14753346
Gene end: 14755992
  
Corresponding Affymetrix probe sets: 10353213 (MoGene1.0st)   1418417_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027062
Ensembl peptide - ENSMUSP00000140741
NCBI entrez gene - 17681     See in Manteia.
MGI - MGI:1333884
RefSeq - XM_006495460
RefSeq - NM_010827
RefSeq - XM_006495458
RefSeq Peptide - NP_034957
swissprot - O88940
swissprot - A0A087WRR6
Ensembl - ENSMUSG00000025930
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mscENSDARG00000110016Danio rerio
 MSCENSGALG00000037777Gallus gallus
 MSCENSG00000178860Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tcf21 / O35437 / Transcription factor 21 / O43680*ENSMUSG0000004568050
Tcf24 / transcription factor 24 / Q7RTU0*ENSMUSG0000009903224
Tcf23 / Q9JLR5 / Transcription factor 23 / Q7RTU1*ENSMUSG0000000664221


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0014707 branchiomeric skeletal muscle development IGI
 biological_processGO:0060021 roof of mouth development IGI
 biological_processGO:0060539 diaphragm development IGI
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21+
Genetic Background: involves: 129 * Black Swiss

 MP:0003924 herniated diaphragm "protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004234 abnormal masticatory muscle morphology "any structural anomaly of any of the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004236 absent masseter muscle "absence of the masticatory muscle of posterior cheek" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004237 abnormal pterygoid muscle morphology "any structural anomaly of the muscles descending from the sphenoid bone to the lower jaw including the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle. Action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004238 absent pterygoid muscle "absence of either the internal or external or of both pterygoid muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0004240 absent temporalis muscle "absence of the superior-most masticatory muscle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0009885 abnormal palatal shelf elevation "any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Msctm1Eno/Msctm1Eno,Tcf21tm2Eno/Tcf21tm2Eno
Genetic Background: involves: 129 * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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