Manteia

ENSMUSG00000045680

Mus musculus

Features

Gene ID:	ENSMUSG00000045680

Biological name :	Tcf21

Synonyms :	O35437 / Tcf21 / Transcription factor 21

Possible biological names infered from orthology :	O43680

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	A3
Gene start:	22817281
Gene end:	22820174

Corresponding Affymetrix probe sets:	10368240 (MoGene1.0st) 1417447_at (Mouse Genome 430 2.0 Array) 1458887_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000151767 Ensembl peptide - ENSMUSP00000053178 NCBI entrez gene - 21412 See in Manteia. MGI - MGI:1202715 RefSeq - NM_011545 RefSeq Peptide - NP_035675 swissprot - A0A1W2P7S0 swissprot - O35437 Ensembl - ENSMUSG00000045680

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tcf21	ENSDARG00000036869	Danio rerio
TCF21	ENSGALG00000029024	Gallus gallus
TCF21	ENSG00000118526	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Msc / O88940 / Musculin / O60682*	ENSMUSG00000025930	56
Tcf24 / transcription factor 24 / Q7RTU0*	ENSMUSG00000099032	26
Tcf23 / Q9JLR5 / Transcription factor 23 / Q7RTU1*	ENSMUSG00000006642	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR036638	Helix-loop-helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0001657	ureteric bud development	IMP
biological_process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP
biological_process	GO:0001763	morphogenesis of a branching structure	IMP
biological_process	GO:0001822	kidney development	IMP
biological_process	GO:0001944	vasculature development	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007530	sex determination	IMP
biological_process	GO:0007548	sex differentiation	IMP
biological_process	GO:0009887	animal organ morphogenesis	IMP
biological_process	GO:0014707	branchiomeric skeletal muscle development	IGI
biological_process	GO:0030855	epithelial cell differentiation	IMP
biological_process	GO:0031063	regulation of histone deacetylation	IC
biological_process	GO:0032835	glomerulus development	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0048286	lung alveolus development	IMP
biological_process	GO:0048536	spleen development	IMP
biological_process	GO:0048557	embryonic digestive tract morphogenesis	IEA
biological_process	GO:0048608	reproductive structure development	IMP
biological_process	GO:0048732	gland development	IEA
biological_process	GO:0060008	Sertoli cell differentiation	IEA
biological_process	GO:0060021	roof of mouth development	IGI
biological_process	GO:0060425	lung morphogenesis	IMP
biological_process	GO:0060426	lung vasculature development	IMP
biological_process	GO:0060435	bronchiole development	IMP
biological_process	GO:0060539	diaphragm development	IGI
biological_process	GO:0060541	respiratory system development	IMP
biological_process	GO:0060766	negative regulation of androgen receptor signaling pathway	IDA
biological_process	GO:0072162	metanephric mesenchymal cell differentiation	IMP
biological_process	GO:0072277	metanephric glomerular capillary formation	IMP
cellular_component	GO:0005634	nucleus	ISO
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0042826	histone deacetylase binding	IPI
molecular_function	GO:0043425	bHLH transcription factor binding	IEA
molecular_function	GO:0046983	protein dimerization activity	IEA
molecular_function	GO:0050681	androgen receptor binding	IPI
molecular_function	GO:0070888	E-box binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dkk3^tm1Cni/Dkk3^tm1Cni,Kcnk3^tm1Sgb/Kcnk3^tm1Sgb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000277	abnormal heart shape	"malformation of the form or the patterning of the heart" [J:18048]	Show Allelic Composition: Dkk3^tm1Cni/Dkk3^tm1Cni,Kcnk3^tm1Sgb/Kcnk3^tm1Sgb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000528	delayed kidney development	"late onset of the induction and/or differentiation of the kidney" [J:18048]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000530	abnormal kidney vasculature	"malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000536	hydroureter	"distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0000729	abnormal myogenesis	"anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0001116	small gonad	"reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001178	pulmonary hypoplasia	"reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0001184	absent alveoli	"missing section of the lung in which gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0001939	secondary sex reversal	"secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001953	respiratory failure	"cessation of or failure to commence breathing" [MGI:cls, J:60159]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ Genetic Background: involves: C57BL/6 * C57BL/6J * SJL
MP:0002080	prenatal lethality	"death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺ Genetic Background: B6(AKR)-Apc^Min Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Msc^tm1Eno/Msc^tm1Eno,Tcf21^tm2Eno/Tcf21⁺ Genetic Background: involves: 129 * Black Swiss Allelic Composition: Tcf21^{tm3.1(cre/Esr1)Eno}/Tcf21⁺ Genetic Background:* involves: 129S6/SvEvTac * C57BL/6
MP:0002652	thin myocardial wall	"thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dkk3^tm1Cni/Dkk3^tm1Cni,Kcnk3^tm1Sgb/Kcnk3^tm1Sgb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002828	abnormal glomerular capsule	"anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002995	primary sex reversal	"gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003014	abnormal kidney medulla morphology	"anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003605	fused kidneys		Show Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0004007	abnormal lung vasculature	"malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004194	abnormal kidney pelvis morphology	"any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0004234	abnormal masticatory muscle morphology	"any structural anomaly of any of the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0004236	absent masseter muscle	"absence of the masticatory muscle of posterior cheek" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0004237	abnormal pterygoid muscle morphology	"any structural anomaly of the muscles descending from the sphenoid bone to the lower jaw including the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle. Action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0004238	absent pterygoid muscle	"absence of either the internal or external or of both pterygoid muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0004240	absent temporalis muscle	"absence of the superior-most masticatory muscle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0004505	decreased renal glomerulus number	"reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004754	abnormal kidney collecting duct	"any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptch1^tm1Bjw/Ptch1^tm1Bjw,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ
MP:0004756	abnormal proximal convoluted tubule morphology	"any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004970	kidney atrophy	"wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005244	hemopericardium	"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * C57BL/6
MP:0005264	glomerulosclerosis	"hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005326	abnormal podocytes	"anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005652	sex reversal	"development of the reproductive system is inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006032	abnormal ureteric bud morphology	"anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006382	abnormal lung epithelium morphology	"any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0006419	disorganized testis cords	"derangement of the pattern of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008059	abnormal podocyte foot process morphology	"any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008140	podocyte foot process effacement	"thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0008727	enlarged right atrium	"increased size of the right upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * C57BL/6
MP:0009323	abnormal spleen development	"aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm2.1Seq/Tcf21^tm1Jrt,Tg(Nphs2-cre)1Seq/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0009885	abnormal palatal shelf elevation	"any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy,Ntf5^tm1Gdy/Ntf5^tm1Gdy Genetic Background: involves: 129P2/OlaHsd
MP:0010812	absent type II pneumocytes	"absence of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010856	dilated respiratory conducting tubes	"expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010902	abnormal pulmonary alveolar sac morphology	"any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010911	abnormal pulmonary acinus morphology	"any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010976	small lung lobe	"reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010981	abnormal branching involved in ureteric bud morphogenesis	"anomaly in the process in which the branching structure of the ureteric bud is generated and organized" [GO:0001658]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010985	abnormal kidney mesenchyme morphology	"any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011024	abnormal branching involved in lung morphogenesis	"anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized" [MGI:csmith]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0011028	impaired branching involved in bronchus morphogenesis		Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011038	impaired branching involved in alveolar sac morphogenesis		Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss Allelic Composition: Msc^tm1Eno/Msc^tm1Eno,Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss Allelic Composition: Tcf21^{tm3.1(cre/Esr1)Eno}/Tcf21^{tm3.1(cre/Esr1)Eno} Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0011290	decreased nephron number	"reduction in the total number of filtering units of the kidney" [MGI:anna]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011298	ureter hypoplasia	"underdevelopment or reduced size of the ureter, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt,Tcf21^tm1(cre)Seq/Tcf21⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011320	abnormal glomerular capillary morphology	"any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011321	abnormal peritubular capillary morphology	"any structural anomaly of the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure" [MGI:csmith]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011351	absent proximal convoluted tubule brush border	"failure to form a brush border of densely packed microvilli on the luminal surface of epithelial cells of the proximal convoluted tubule" [MGI:anna]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011363	renal glomerulus atrophy	"acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Tal1^tm2Wehi/Tal1^tm2Wehi Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * Black Swiss
MP:0011727	ectopic ovary	"appearance of an ovary in a region where it is not normally found (topographical anomaly)" [MGI:csmith]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0011760	abnormal ureteric bud tip morphology	"any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis" [MGI:anna]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012515	abnormal heart apex morphology	"any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna]	Show Allelic Composition: Tcf21^tm2Eno/Tcf21^tm2Eno Genetic Background: involves: 129 * C57BL/6
MP:0020491	abnormal ovary topology	"any anomaly in the position of the ovary in relation to other structures" [MGI:smb]	Show Allelic Composition: Tcf21^tm1Jrt/Tcf21^tm1Jrt Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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