ENSG00000118526


Homo sapiens

Features
Gene ID: ENSG00000118526
  
Biological name :TCF21
  
Synonyms : O43680 / TCF21 / transcription factor 21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q23.2
Gene start: 133889138
Gene end: 133895553
  
Corresponding Affymetrix probe sets: 204931_at (Human Genome U133 Plus 2.0 Array)   229529_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000237316
Ensembl peptide - ENSP00000356857
NCBI entrez gene - 6943     See in Manteia.
OMIM - 603306
RefSeq - NM_003206
RefSeq - NM_198392
RefSeq Peptide - NP_003197
RefSeq Peptide - NP_938206
swissprot - O43680
Ensembl - ENSG00000118526
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcf21ENSDARG00000036869Danio rerio
 TCF21ENSGALG00000029024Gallus gallus
 Tcf21ENSMUSG00000045680Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MSC / O60682 / musculinENSG0000017886060
TCF24 / Q7RTU0 / transcription factor 24ENSG0000026178725
TCF23 / Q7RTU1 / transcription factor 23ENSG0000016379224


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001657 ureteric bud development ISS
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0001763 morphogenesis of a branching structure ISS
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0001944 vasculature development ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007530 sex determination ISS
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0014707 branchiomeric skeletal muscle development ISS
 biological_processGO:0030855 epithelial cell differentiation ISS
 biological_processGO:0032835 glomerulus development ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048286 lung alveolus development ISS
 biological_processGO:0048536 spleen development ISS
 biological_processGO:0048557 embryonic digestive tract morphogenesis ISS
 biological_processGO:0048608 reproductive structure development ISS
 biological_processGO:0048732 gland development ISS
 biological_processGO:0060008 Sertoli cell differentiation ISS
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0060425 lung morphogenesis ISS
 biological_processGO:0060426 lung vasculature development ISS
 biological_processGO:0060435 bronchiole development ISS
 biological_processGO:0060539 diaphragm development ISS
 biological_processGO:0060541 respiratory system development ISS
 biological_processGO:0060766 negative regulation of androgen receptor signaling pathway ISS
 biological_processGO:0072162 metanephric mesenchymal cell differentiation ISS
 biological_processGO:0072277 metanephric glomerular capillary formation ISS
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0046983 protein dimerization activity ISS
 molecular_functionGO:0050681 androgen receptor binding ISS
 molecular_functionGO:0070888 E-box binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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