ENSMUSG00000025939


Mus musculus

Features
Gene ID: ENSMUSG00000025939
  
Biological name :Ube2w
  
Synonyms : Ube2w / ubiquitin-conjugating enzyme E2W (putative)
  
Possible biological names infered from orthology : Q96B02 / ubiquitin conjugating enzyme E2 W
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A3
Gene start: 16540790
Gene end: 16619489
  
Corresponding Affymetrix probe sets: 10353288 (MoGene1.0st)   1426398_at (Mouse Genome 430 2.0 Array)   1443188_at (Mouse Genome 430 2.0 Array)   1452054_at (Mouse Genome 430 2.0 Array)   1457544_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138110
Ensembl peptide - ENSMUSP00000112741
Ensembl peptide - ENSMUSP00000121573
NCBI entrez gene - 66799     See in Manteia.
MGI - MGI:1914049
RefSeq - XM_017322048
RefSeq - NM_001271016
RefSeq - NM_001271017
RefSeq - NM_025773
RefSeq - XM_017322047
RefSeq Peptide - NP_001257945
RefSeq Peptide - NP_001257946
RefSeq Peptide - NP_080049
swissprot - D6RCG4
swissprot - S4R177
swissprot - A0A0A0MQF3
Ensembl - ENSMUSG00000025939
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flj11011lENSDARG00000045360Danio rerio
 ube2wENSDARG00000044923Danio rerio
 UBE2WENSGALG00000040097Gallus gallus
 UBE2WENSG00000104343Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube2c / Q9D1C1 / ubiquitin-conjugating enzyme E2C / O00762*ENSMUSG0000000140328


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005730 nucleolus IEA


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0009605 decreased keratohyalin granule number "reduced number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Igsf11tm1d(KOMP)Wtsi/Igsf11tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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