ENSMUSG00000001403


Mus musculus

Features
Gene ID: ENSMUSG00000001403
  
Biological name :Ube2c
  
Synonyms : Q9D1C1 / Ube2c / ubiquitin-conjugating enzyme E2C
  
Possible biological names infered from orthology : O00762
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 164769898
Gene end: 164778822
  
Corresponding Affymetrix probe sets: 10478572 (MoGene1.0st)   1452954_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001439
Ensembl peptide - ENSMUSP00000085581
NCBI entrez gene - 68612     See in Manteia.
MGI - MGI:1915862
RefSeq - NM_026785
RefSeq Peptide - NP_081061
swissprot - A2A4Z1
swissprot - A2A4Z0
swissprot - Q9D1C1
Ensembl - ENSMUSG00000001403
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2cENSDARG00000114670Danio rerio
 UBE2CENSGALG00000026380Gallus gallus
 UBE2CENSG00000175063Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube2w / ubiquitin-conjugating enzyme E2W (putative) / Q96B02* / ubiquitin conjugating enzyme E2 W*ENSMUSG0000002593928


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010458 exit from mitosis ISO
 biological_processGO:0010994 free ubiquitin chain polymerization ISS
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IBA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IBA
 biological_processGO:0031536 positive regulation of exit from mitosis ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:0070979 protein K11-linked ubiquitination ISO
 cellular_componentGO:0000151 ubiquitin ligase complex ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005680 anaphase-promoting complex ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity ISO


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Txndc5tm1.1(KOMP)Vlcg/Txndc5tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Txndc5tm1.1(KOMP)Vlcg/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Txndc5tm1.1(KOMP)Vlcg/Txndc5tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Txndc5tm1.1(KOMP)Vlcg/Ucd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Ube2ctm1.1(KOMP)Wtsi/Ube2c+
Genetic Background: C57BL/6N-Ube2ctm1.1(KOMP)Wtsi/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Trip13tm1.1(KOMP)Vlcg/Trip13tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Trip13tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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