ENSG00000175063


Homo sapiens

Features
Gene ID: ENSG00000175063
  
Biological name :UBE2C
  
Synonyms : O00762 / UBE2C / ubiquitin conjugating enzyme E2 C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 45812576
Gene end: 45816957
  
Corresponding Affymetrix probe sets: 202954_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361649
Ensembl peptide - ENSP00000348838
Ensembl peptide - ENSP00000385878
Ensembl peptide - ENSP00000479486
Ensembl peptide - ENSP00000243893
Ensembl peptide - ENSP00000333975
Ensembl peptide - ENSP00000335674
NCBI entrez gene - 11065     See in Manteia.
OMIM - 605574
RefSeq - NM_001281742
RefSeq - NM_001281741
RefSeq - NM_007019
RefSeq - NM_181799
RefSeq - NM_181800
RefSeq - NM_181801
RefSeq Peptide - NP_861516
RefSeq Peptide - NP_001268670
RefSeq Peptide - NP_001268671
RefSeq Peptide - NP_008950
RefSeq Peptide - NP_861515
RefSeq Peptide - NP_861517
swissprot - O00762
swissprot - Q5TZN3
swissprot - A0A0A0MSE8
swissprot - K4DI81
swissprot - A0A087WVK1
Ensembl - ENSG00000175063
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2cENSDARG00000114670Danio rerio
 UBE2CENSGALG00000026380Gallus gallus
 Ube2cENSMUSG00000001403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2W / Q96B02 / ubiquitin conjugating enzyme E2 WENSG0000010434329
AC022826.2ENSG0000025867728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010458 exit from mitosis IMP
 biological_processGO:0010994 free ubiquitin chain polymerization IDA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IBA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IDA
 biological_processGO:0031536 positive regulation of exit from mitosis IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity TAS
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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