ENSMUSG00000025982


Mus musculus

Features
Gene ID: ENSMUSG00000025982
  
Biological name :Sf3b1
  
Synonyms : Sf3b1 / splicing factor 3b, subunit 1
  
Possible biological names infered from orthology : O75533
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C1.2
Gene start: 54985169
Gene end: 55027481
  
Corresponding Affymetrix probe sets: 10354704 (MoGene1.0st)   1418561_at (Mouse Genome 430 2.0 Array)   1418562_at (Mouse Genome 430 2.0 Array)   1440818_s_at (Mouse Genome 430 2.0 Array)   1449138_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139469
Ensembl peptide - ENSMUSP00000027127
NCBI entrez gene - 81898     See in Manteia.
MGI - MGI:1932339
RefSeq - NM_031179
RefSeq - XM_017312972
RefSeq - XM_017312973
RefSeq Peptide - NP_112456
swissprot - G5E866
swissprot - A0A087WNS2
Ensembl - ENSMUSG00000025982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sf3b1ENSDARG00000056138Danio rerio
 SF3B1ENSGALG00000008038Gallus gallus
 SF3B1ENSG00000115524Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR015016  Splicing factor 3B subunit 1
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005686 U2 snRNP IEA
 cellular_componentGO:0005689 U12-type spliceosomal complex IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0034693 U11/U12 snRNP IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+
Genetic Background: involves: C57BL/6

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pcgf2tm1Hko/Pcgf2+,Sf3b1tm1Hko/Sf3b1+
Genetic Background: involves: C57BL/6

 MP:0008389 hypochromic macrocytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Spry1tm1.1Jdli/Spry1tm1.1Jdli
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
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Allelic Composition: Aim2tm1.2Arte/Aim2tm1.2Arte,Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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