ENSMUSG00000026155


Mus musculus

Features
Gene ID: ENSMUSG00000026155
  
Biological name :Smap1
  
Synonyms : Q91VZ6 / small ArfGAP 1 / Smap1
  
Possible biological names infered from orthology : Q8IYB5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A5
Gene start: 23844846
Gene end: 23922317
  
Corresponding Affymetrix probe sets: 10353533 (MoGene1.0st)   1423956_at (Mouse Genome 430 2.0 Array)   1431744_a_at (Mouse Genome 430 2.0 Array)   1432029_a_at (Mouse Genome 430 2.0 Array)   1453998_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027339
Ensembl peptide - ENSMUSP00000117875
NCBI entrez gene - 98366     See in Manteia.
MGI - MGI:2138261
RefSeq - XM_006496362
RefSeq - NM_001290683
RefSeq - NM_028534
RefSeq Peptide - NP_001277612
RefSeq Peptide - NP_082810
swissprot - Q91VZ6
swissprot - D3YVX4
Ensembl - ENSMUSG00000026155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smap1ENSDARG00000031302Danio rerio
 SMAP1ENSGALG00000015959Gallus gallus
 SMAP1ENSG00000112305Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smap2 / Q7TN29 / small ArfGAP 2 / Q8WU79*ENSMUSG0000003287048
Adap2 / Q8R2V5 / Arf-GAP with dual PH domain-containing protein 2 / Q9NPF8* / ArfGAP with dual PH domains 2*ENSMUSG0000002070919
Adap1 / ArfGAP with dual PH domains 1 / O75689*ENSMUSG0000005641317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IDA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030276 clathrin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nek8tm1Bei/Nek8jck
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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