ENSMUSG00000032870


Mus musculus

Features
Gene ID: ENSMUSG00000032870
  
Biological name :Smap2
  
Synonyms : Q7TN29 / small ArfGAP 2 / Smap2
  
Possible biological names infered from orthology : Q8WU79
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 120968317
Gene end: 121017247
  
Corresponding Affymetrix probe sets: 10515994 (MoGene1.0st)   1450675_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035800
NCBI entrez gene - 69780     See in Manteia.
MGI - MGI:1917030
RefSeq - XM_006503380
RefSeq - NM_133716
RefSeq - XM_006503378
RefSeq Peptide - NP_598477
swissprot - Q7TN29
Ensembl - ENSMUSG00000032870
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smap2ENSDARG00000061446Danio rerio
 SMAP2ENSGALG00000029244Gallus gallus
 SMAP2ENSG00000084070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smap1 / Q91VZ6 / small ArfGAP 1 / Q8IYB5*ENSMUSG0000002615549
Adap1 / ArfGAP with dual PH domains 1 / O75689*ENSMUSG0000005641318
Adap2 / Q8R2V5 / Arf-GAP with dual PH domain-containing protein 2 / Q9NPF8* / ArfGAP with dual PH domains 2*ENSMUSG0000002070917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Gfertm1.1Crg/Gfertm1.1Crg,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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