ENSMUSG00000026159


Mus musculus

Features
Gene ID: ENSMUSG00000026159
  
Biological name :Agfg1
  
Synonyms : Agfg1 / Arf-GAP domain and FG repeat-containing protein 1 / Q8K2K6
  
Possible biological names infered from orthology : ArfGAP with FG repeats 1 / P52594
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 82839483
Gene end: 82901182
  
Corresponding Affymetrix probe sets: 10347873 (MoGene1.0st)   1426922_s_at (Mouse Genome 430 2.0 Array)   1426923_at (Mouse Genome 430 2.0 Array)   1434840_at (Mouse Genome 430 2.0 Array)   1442489_at (Mouse Genome 430 2.0 Array)   1452237_at (Mouse Genome 430 2.0 Array)   1452238_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140473
Ensembl peptide - ENSMUSP00000140170
Ensembl peptide - ENSMUSP00000140678
Ensembl peptide - ENSMUSP00000141157
Ensembl peptide - ENSMUSP00000140785
Ensembl peptide - ENSMUSP00000070250
Ensembl peptide - ENSMUSP00000109071
Ensembl peptide - ENSMUSP00000139503
NCBI entrez gene - 15463     See in Manteia.
MGI - MGI:1333754
RefSeq - XM_017316914
RefSeq - XM_006496432
RefSeq - XM_006496433
RefSeq - XM_006496434
RefSeq - XM_006496435
RefSeq - XM_006496436
RefSeq - XM_006496438
RefSeq - XM_006496439
RefSeq - XM_006496440
RefSeq - NM_001310713
RefSeq - NM_010472
RefSeq - XM_006496430
RefSeq - XM_006496431
RefSeq Peptide - NP_001297642
RefSeq Peptide - NP_001334006
RefSeq Peptide - NP_034602
swissprot - Q8K2K6
swissprot - A0A087WSR7
swissprot - A0A087WNV1
swissprot - A0A087WRL1
swissprot - A0A087WR52
Ensembl - ENSMUSG00000026159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agfg1aENSDARG00000030020Danio rerio
 agfg1bENSDARG00000019526Danio rerio
 AGFG1ENSGALG00000003052Gallus gallus
 AGFG1ENSG00000173744Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agfg2 / Q80WC7 / Arf-GAP domain and FG repeat-containing protein 2 / O95081* / ArfGAP with FG repeats 2*ENSMUSG0000002972236


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007289 spermatid nucleus differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045109 intermediate filament organization IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042995 cell projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009233 enlarged sperm head "increased size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009833 absent sperm mitochondrial sheath "absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum" [PMID:14581499]
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Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009839 multiflagellated sperm "presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ikbkbtm1Ver/Ikbkbtm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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