ENSMUSG00000026176


Mus musculus

Features
Gene ID: ENSMUSG00000026176
  
Biological name :Ctdsp1
  
Synonyms : Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 / Ctdsp1 / P58466
  
Possible biological names infered from orthology : CTD small phosphatase 1 / Q9GZU7
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 74391509
Gene end: 74397285
  
Corresponding Affymetrix probe sets: 10347351 (MoGene1.0st)   10347362 (MoGene1.0st)   1452055_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027367
Ensembl peptide - ENSMUSP00000114526
NCBI entrez gene - 227292     See in Manteia.
MGI - MGI:2654470
RefSeq - NM_153088
RefSeq Peptide - NP_694728
swissprot - F7AIT6
swissprot - P58466
swissprot - Q5I0X8
Ensembl - ENSMUSG00000026176
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctdsp1ENSDARG00000040674Danio rerio
 CTDSP1ENSGALG00000027768Gallus gallus
 CTDSP1ENSG00000144579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctdspl / P58465 / CTD small phosphatase-like protein / O15194* / CTD small phosphatase like*ENSMUSG0000004740969
Ctdsp2 / Q8BX07 / Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 / O14595* / CTD small phosphatase 2*ENSMUSG0000007842961
Q3TP92 / Ctdnep1 / CTD nuclear envelope phosphatase 1 / O95476*ENSMUSG0000001855932


Protein motifs (from Interpro)
Interpro ID Name
 IPR004274  FCP1 homology domain
 IPR011948  Dullard phosphatase domain, eukaryotic
 IPR023214  HAD superfamily
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IDA
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008420 CTD phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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