ENSMUSG00000018559


Mus musculus

Features
Gene ID: ENSMUSG00000018559
  
Biological name :Ctdnep1
  
Synonyms : Ctdnep1 / CTD nuclear envelope phosphatase 1 / Q3TP92
  
Possible biological names infered from orthology : O95476
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69981156
Gene end: 69990601
  
Corresponding Affymetrix probe sets: 10377681 (MoGene1.0st)   1452100_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104234
Ensembl peptide - ENSMUSP00000137199
NCBI entrez gene - 67181     See in Manteia.
MGI - MGI:1914431
RefSeq - NM_026017
RefSeq Peptide - NP_080293
swissprot - J3QPC9
swissprot - Q3TP92
Ensembl - ENSMUSG00000018559
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctdnep1bENSDARG00000035781Danio rerio
 Q5U395ENSDARG00000016519Danio rerio
 O95476ENSG00000175826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctdspl / P58465 / CTD small phosphatase-like protein / O15194* / CTD small phosphatase like*ENSMUSG0000004740935
Ctdsp1 / P58466 / Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 / Q9GZU7* / CTD small phosphatase 1*ENSMUSG0000002617634
Ctdsp2 / Q8BX07 / Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 / O14595* / CTD small phosphatase 2*ENSMUSG0000007842934


Protein motifs (from Interpro)
Interpro ID Name
 IPR004274  FCP1 homology domain
 IPR011948  Dullard phosphatase domain, eukaryotic
 IPR023214  HAD superfamily
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006998 nuclear envelope organization IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 cellular_componentGO:0071595 Nem1-Spo7 phosphatase complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IBA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Depolymerisation of the Nuclear Lamina


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Bmp4tm1Blh/Bmp4+,Ctdnep1tm1Ryn/Ctdnep1tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ctdnep1tm1Ryn/Ctdnep1+,Wnt3tm1Brd/Wnt3+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
Show

Allelic Composition: Lig1m1Anu/Lig1m1Anu
Genetic Background: involves: C3H/HeH * C57BL/6JAnu

Allelic Composition: Ctdnep1tm2Ryn/Ctdnep1tm2Ryn
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
Show

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011371 decreased kidney apoptosis "decrease in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Ctdnep1tm3Ryn/Ctdnep1tm3Ryn,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036810 Q3UJ81 / Cnep1r1 / Nuclear envelope phosphatase-regulatory subunit 1 / Q8N9A8* / CTD nuclear envelope phosphatase 1 regulatory subunit 1*  / complex
 ENSMUSG00000020593 Lpin1 / Mus musculus lipin 1 (Lpin1), transcript variant 4, mRNA. / Q14693* / lipin 1*  / reaction






 

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