ENSMUSG00000026473


Mus musculus

Features
Gene ID: ENSMUSG00000026473
  
Biological name :Glul
  
Synonyms : Glul / Glutamine synthetase / P15105
  
Possible biological names infered from orthology : glutamate-ammonia ligase / P15104
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G3
Gene start: 153899944
Gene end: 153909723
  
Corresponding Affymetrix probe sets: 10350753 (MoGene1.0st)   10374453 (MoGene1.0st)   1426235_a_at (Mouse Genome 430 2.0 Array)   1426236_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083375
Ensembl peptide - ENSMUSP00000123157
Ensembl peptide - ENSMUSP00000114377
NCBI entrez gene - 14645     See in Manteia.
MGI - MGI:95739
RefSeq - NM_008131
RefSeq Peptide - NP_032157
swissprot - D3Z121
swissprot - D3YVK1
swissprot - P15105
Ensembl - ENSMUSG00000026473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glulaENSDARG00000099776Danio rerio
 glulbENSDARG00000100003Danio rerio
 GLULENSGALG00000043754Gallus gallus
 GLULENSG00000135821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008146  Glutamine synthetase, catalytic domain
 IPR008147  Glutamine synthetase, beta-Grasp domain
 IPR014746  Glutamine synthetase/guanido kinase, catalytic domain
 IPR027302  Glutamine synthetase, N-terminal conserved site
 IPR027303  Glutamine synthetase, glycine-rich site
 IPR036651  Glutamine synthetase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006536 glutamate metabolic process IEA
 biological_processGO:0006542 glutamine biosynthetic process IEA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009267 cellular response to starvation IEP
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0019676 ammonia assimilation cycle IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0097386 glial cell projection IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004351 glutamate decarboxylase activity IEA
 molecular_functionGO:0004356 glutamate-ammonia ligase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016595 glutamate binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045503 dynein light chain binding IEA


Pathways (from Reactome)
Pathway description
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Glultm1.1Geno/Glultm1.1Geno,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Glultm3Whla/Glultm1Whla,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001765 abnormal ion homeostasis "anomaly in the state of equilibrium in the body with respect to charged molecules in the fluids and tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Glultm3Whla/Glultm1Whla,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003106 abnormal fear-related response "altered emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Glultm1.1Geno/Glultm1.1Geno,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Glultm1.1Geno/Glultm1.1Geno,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Glultm1.1Geno/Glultm1.1Geno,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * C57BL/6J * DBA

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Glultm3Whla/Glultm1Whla,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Vangl2Lp-2J/Vangl2+
Genetic Background: B6.Cg-Vangl2Lp-2J/GrsrJ

Allelic Composition: Glultm3Whla/Glultm3Whla,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Clcn2tm1Tjj/Clcn2tm1Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026473 Glul / P15105 / Glutamine synthetase / P15104* / glutamate-ammonia ligase*  / complex






 

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