Manteia

ENSMUSG00000026604

Mus musculus

Features

Gene ID:	ENSMUSG00000026604

Biological name :	Ptpn14

Synonyms :	Ptpn14 / Q62130 / Tyrosine-protein phosphatase non-receptor type 14

Possible biological names infered from orthology :	protein tyrosine phosphatase, non-receptor type 14 / Q15678

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	H6
Gene start:	189728268
Gene end:	189876695

Corresponding Affymetrix probe sets:	10352661 (MoGene1.0st) 1421499_a_at (Mouse Genome 430 2.0 Array) 1436442_at (Mouse Genome 430 2.0 Array) 1455359_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000027898 Ensembl peptide - ENSMUSP00000095051 NCBI entrez gene - 19250 See in Manteia. MGI - MGI:102467 RefSeq - XM_006497134 RefSeq - NM_008976 RefSeq - XM_006497130 RefSeq - XM_006497131 RefSeq - XM_006497133 RefSeq - XM_006497129 RefSeq Peptide - NP_033002 swissprot - Q62130 swissprot - A0A0R4J080 Ensembl - ENSMUSG00000026604

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PTPN14	ENSGALG00000009784	Gallus gallus
PTPN14	ENSG00000152104	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ptpn21 / protein tyrosine phosphatase, non-receptor type 21 / Q16825*	ENSMUSG00000021009	54
Ptpn13 / protein tyrosine phosphatase, non-receptor type 13 / Q12923*	ENSMUSG00000034573	25
Frmpd2 / FERM and PDZ domain containing 2 / Q68DX3*	ENSMUSG00000108841	13
Frmd6 / Q8C0V9 / FERM domain-containing protein 6 / Q96NE9* / FERM domain containing 6*	ENSMUSG00000048285	9

Protein motifs (from Interpro)

Interpro ID	Name
IPR000242	PTP type protein phosphatase
IPR000299	FERM domain
IPR000387	Tyrosine specific protein phosphatases domain
IPR003595	Protein-tyrosine phosphatase, catalytic
IPR011993	PH-like domain superfamily
IPR014352	FERM/acyl-CoA-binding protein superfamily
IPR014392	Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR016130	Protein-tyrosine phosphatase, active site
IPR018979	FERM, N-terminal
IPR018980	FERM, C-terminal PH-like domain
IPR019747	FERM conserved site
IPR019748	FERM central domain
IPR019749	Band 4.1 domain
IPR029021	Protein-tyrosine phosphatase-like
IPR029071	Ubiquitin-like domain superfamily
IPR035963	FERM superfamily, second domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001946	lymphangiogenesis	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006470	protein dephosphorylation	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IEA
biological_process	GO:0046825	regulation of protein export from nucleus	IEA
biological_process	GO:1903506	regulation of nucleic acid-templated transcription	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
molecular_function	GO:0003712	transcription coregulator activity	IEA
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IEA
molecular_function	GO:0004725	protein tyrosine phosphatase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016791	phosphatase activity	IEA
molecular_function	GO:0030971	receptor tyrosine kinase binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0001731	abnormal postnatal growth	"anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0001788	periorbital edema	"accumulation of an excessive amount of fluid in the area around the orbit " [MGI:tc, J:60896]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0003390	lymphedema	"abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0004106	lymphatic vessel hyperplasia	"increased cell number in lymphatic vessels" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dclre1a^tm1Rleg/Dclre1a^tm1Rleg Genetic Background: involves: 129S7/SvEvBrd
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl
MP:0013292	embryonic lethality prior to organogenesis	"death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]	Show Allelic Composition: Prkab1^{tm1b(KOMP)Wtsi}/Prkab1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Prkab1^{tm1b(KOMP)Wtsi}/Orl

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr