ENSMUSG00000034573


Mus musculus

Features
Gene ID: ENSMUSG00000034573
  
Biological name :Ptpn13
  
Synonyms : protein tyrosine phosphatase, non-receptor type 13 / Ptpn13
  
Possible biological names infered from orthology : Q12923
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 103425192
Gene end: 103598303
  
Corresponding Affymetrix probe sets: 10523595 (MoGene1.0st)   1431791_a_at (Mouse Genome 430 2.0 Array)   1452127_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048119
Ensembl peptide - ENSMUSP00000143571
NCBI entrez gene - 19249     See in Manteia.
MGI - MGI:103293
RefSeq - NM_011204
RefSeq Peptide - NP_035334
swissprot - G5E8B1
swissprot - A0A0G2JGH9
Ensembl - ENSMUSG00000034573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn13ENSDARG00000103699Danio rerio
 PTPN13ENSGALG00000011078Gallus gallus
 PTPN13ENSG00000163629Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Frmpd2 / FERM and PDZ domain containing 2 / Q68DX3*ENSMUSG0000010884119
Ptpn14 / Q62130 / Tyrosine-protein phosphatase non-receptor type 14 / Q15678* / protein tyrosine phosphatase, non-receptor type 14*ENSMUSG0000002660412
Ptpn21 / protein tyrosine phosphatase, non-receptor type 21 / Q16825*ENSMUSG0000002100912
Frmd6 / Q8C0V9 / FERM domain-containing protein 6 / Q96NE9* / FERM domain containing 6*ENSMUSG000000482856


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001478  PDZ domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011019  KIND domain
 IPR011993  PH-like domain superfamily
 IPR012153  Tyrosine-protein phosphatase non-receptor type 13
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rorasg-3J/Rorasg-3J
Genetic Background: C57BL/6J-Rorasg-3J/J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rorasg-3J/Rorasg-3J
Genetic Background: C57BL/6J-Rorasg-3J/J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rorasg-3J/Rorasg-3J
Genetic Background: C57BL/6J-Rorasg-3J/J

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008090 increased T-helper 2 cell number "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rorasg-3J/Rorasg-3J
Genetic Background: C57BL/6J-Rorasg-3J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040268 Q8BUL6 / Plekha1 / Pleckstrin homology domain-containing family A member 1 / Q9HB21* / pleckstrin homology domain containing A1*  / complex






 

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